43 Result(s)

Article

Functional genomics and rheumatoid arthritis: where have we been and where should we go?

Studies in model organisms and humans have begun to reveal the complexity of the transcriptome. In addition to serving as passive templates from which genes are translated, RNA molecules are active, functional...

James N Jarvis, Mark Barton Frank in Genome Medicine (2010)

Article

Disease-associated pathophysiologic structures in pediatric rheumatic diseases show characteristics of scale-free networks seen in physiologic systems: implications for pathogenesis and treatment

While standard reductionist approaches have provided some insights into specific gene polymorphisms and molecular pathways involved in disease pathogenesis, our understanding of complex traits such as atherosc...

Mark Barton Frank, Shirley Wang, Amita Aggarwal, Nicholas Knowlton… in BMC Medical Genomics (2009)

Article

Commentary – ordering lab tests for suspected rheumatic disease

One of the least-appreciated advances in pediatric rheumatology over the past 25 years has been the delineation of the many ways in which children with rheumatic disease differ from adults with the same illnes...

James N Jarvis in Pediatric Rheumatology (2008)

Article

Neutrophils: the forgotten cell in JIA disease pathogenesis

Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease, triggered by aberrant recognition of "self" antigens by T-cells. However, systems biology approaches to this family of dis...

James N Jarvis, Kaiyu Jiang, Howard R Petty, Michael Centola in Pediatric Rheumatology (2007)

Article

A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells

Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a ...

Shelley Lawrence, Yuhong Tang, M Barton Frank, Igor Dozmorov… in Journal of Inflammation (2007)

Article

Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis

Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that s...

James N Jarvis, Howard R Petty, Yuhong Tang… in Arthritis Research & Therapy (2006)

Article

Chronic arthritis in children and adolescents in two Indian health service user populations

High prevalence rates for rheumatoid arthritis, spondyloarthopathies, and systemic lupus erythematosus have been described in American Indian and Alaskan Native adults. The impact of these diseases on American...

Joyce Mauldin, H Dan Cameron, Diane Jeanotte… in BMC Musculoskeletal Disorders (2004)

Article

Clinical utility of antinuclear antibody tests in children

Antinuclear antibody (ANA) tests are frequently used to screen children for chronic inflammatory diseases such as systemic lupus erythematosus (SLE). However, the diagnostic utility of this test is limited bec...

Julie L McGhee, Lauren M Kickingbird, James N Jarvis in BMC Pediatrics (2004)

Article

Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis

Juvenile rheumatoid arthritis (JRA) has a complex, poorly characterized pathophysiology. Modeling of transcriptosome behavior in pathologic specimens using microarrays allows molecular dissection of complex au...

James N Jarvis, Igor Dozmorov, Kaiyu Jiang, Mark Barton Frank… in Arthritis Res Ther (2003)

Article

Phosphorylation of the Complement Receptor, CR1 (CD35), and Its Association with the Syk Tyrosine Kinase in Immune Complex-Stimulated HL-60 Cells

James N Jarvis, Sui-Hui Wang in Pediatric Research (1999)

Article

Activation of Human Umbilical Vein Endothelial Cells by C1q-Bearing Immune Complexes

James N Jarvis, Suhong **ao in Pediatric Research (1999)

Article

Role of Immune Complex Size and Complement Binding in Regulating Monocyte Responses to Immune Complexes • 1982

James N Jarvis, Wenlian Wang, Alit Amit, ChengSu Xu in Pediatric Research (1998)

Article

Human Choriocarcinoma JAR Cells Constitutively Express Pro-Interleukin-1β That Can Be Released with Fcγ Receptor Engagement

Some authors have suggested that fetally derived syncytiotrophoblasts, which form the barrier between mother and the fetus, are an integral part of a complex macrophage-cytokine network involving maternal leuk...

James N Jarvis, Chengsu Xu, Lin Zhao, Madonna Iobidze… in Pediatric Research (1998)

Article

Complement Opsonization Reduces the Pro-Inflammatory Capacity of Immune Complexes 1841

James N. Jarvis, Cheng Su Xu, Wenlian Wang, Alit Amit… in Pediatric Research (1997)

Article

Influence of Size and C4b Binding on the Proinflammatory Properties of Immune Complexes 1839

James N. Jarvis, Alit Amit, Julie McLaughlin, ChengSu Xu… in Pediatric Research (1997)

Article

Juvenile Rheumatoid Arthritis in African-American Children • 1849

Margaret M. Schwartz, Pam Davis, Pippa Simpson, Paul Wooley… in Pediatric Research (1997)

Article

Direct Quantification of Complement Binding to Immune Complexes 1840

James N. Jarvis, ChengSu Xu, Alit Amit in Pediatric Research (1997)

Article

rtPCR ANALYSIS OF ONCOGENE AND TRANSCRIPTION FACTOR EXPRESSION IN NUCLEATED FETAL BLOOD CELLS. • 1714

James N Jarvis, Heide T Moore, Lin Zhao, Stan Berry in Pediatric Research (1996)

Article

INDUCTION OF IL-8 FROM PROMONOCYTIC U937 CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS BY SOLUBLE IMMUNE COMPLEXES. • 2345

James N Jarvis, Cheng Su Xu in Pediatric Research (1996)

Article

TROPHOBLAST-LIKE JAR CELLS CONTAIN PRO-IL-1 β WHICH IS RELEASED WITH FcγR ENGAGEMENT. † 351

James N Jarvis, Heide T Moore, Lin Zhao, Cheng Su Xu in Pediatric Research (1996)