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Article
The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation
Mindin, a secreted, highly conserved extracellular matrix (ECM) protein, exerts a broad spectrum of effects on the innate immune system. However, its function in colorectal cancer (CRC) progression is not well...
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Article
Energies and Spectral Lines for the States of 4s 24p 2, 4s4p 3, and 4s 24p4d Configurations in Ge-Like Te, Xe, and Ba Ions
The energy levels, wavelengths, transition rates, and line strengths have been calculated for the 4s 24p 2–4s4p 3 and 4s ...
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Article
Half-Metallicity of the Fe-Based Single Atomic Chains in CoFeTiAl Quaternary Semiconductor
In this work, the Fe-based single atomic chains are designed in the semiconductive CoFeTiAl quaternary Heusler matrix by substituting Ti, Al, or Ti-Al with Fe in [001] crystallographic direction. We have inves...
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Article
Open AccessGenetic characterization of cysteine-rich type-b avenin-like protein coding genes in common wheat
The wheat avenin-like proteins (ALP) are considered atypical gluten constituents and have shown positive effects on dough properties revealed using a transgenic approach. However, to date the genetic architect...
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Article
Open AccessElevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcri...
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Article
Features of patients with inflammatory bowel diseases who develop hemophagocytic lymphohistiocytosis
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Article
Enhanced magnetoelastic effect in Laves (Tb,Dy)Fe2 alloys with the joint introduction of Pr and Nd
The structural and magnetoelastic properties of (Tb0.3Dy0.7)1−x(Pr0.5Nd0.5)xFe1.93 (0 ≤ x ≤ 0.20) polycrystalline alloys have been investigated by means of X-ray diffraction (XRD), a vibrating sample magnetomete...
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Article
A novel THz spectroscopy recognition method for transgenic organisms based on APSO combined with SVM
Currently, the transgenic products detection methods are mostly based on visible/near-infrared light spectrum. In addition, it is hard to set up the parameters in the support vector machine (SVM) model and the...
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Article
Open AccessLoss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis
Altered hepatic lipogenesis is associated with metabolic diseases such as obesity and hepatosteatosis. Insulin resistance and compensatory hyperinsulinaemia are key drivers of these metabolic imbalances. Fas a...
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Article
Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population
Genetic factors play an important role in our predisposition to cancer. Genome-wide association studies have linked the chromosome 15q25.1 locus to lung cancer susceptibility and implicated proteasome subunit ...
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Article
Reinvestigation of the collective band structures in odd-odd 138Pm nucleus
The high-spin states in the odd-odd 138Pm nucleus have been reinvestigated via the 124Te(19F, 5n) reaction at the beam energy of 103 MeV. Most of the known transitions and levels are confirmed. A number of bands ...
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Article
Structure and magnetostriction of Tb0.4Nd0.6(Fe0.8Co0.2) x alloys
Structural, magnetic and magnetostrictive properties of Tb0.4Nd0.6(Fe0.8Co0.2) x (1.50 ≤ x ≤ 1.90) alloys have been investigated by means of X-ray diffraction (XRD), a vibrating...
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Article
Level structure of 86Sr
The high-spin states in 86Sr have been investigated by using in-beam \( \gamma\) -ray spectroscopy with the 82Se(9Be, 5n
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Article
Short-Term High-Temperature Tensile Tests and Prediction of Long-Term Strength of Welded Joints of Dissimilar Steels T92/HR3C
The microstructures, surfaces and types of fracture of welded joints of dissimilar steels T92/HR3C are studied after short-term tests at 500 – 650°C. A pioneer equation is obtained for describing the long-term...
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Article
Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway
Salmonella have been demonstrated to inhibit tumor growth. However, the mechanism of Salmonella-induced tumor cell death is less defined. Autophagy is a cellular process that mediates the degradation of long-live...
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Article
Cloning of 9-cis-epoxycarotenoid dioxygenase gene (TaNCED1) from wheat and its heterologous expression in tobacco
Abscisic acid (ABA) regulates plant responses to various environmental stresses. Oxidative cleavage of cis-epoxycarotenoids catalyzed by 9-cis-epoxycarotenoid dioxygenase (NCED) is the critical step in the biosyn...
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Article
Research on competition diffusion of the multiple-advanced manufacturing mode in a cluster environment
This paper deals with competition diffusion of multiple-advanced manufacturing modes in a cluster environment, to reveal the competition diffusion rules of the advanced manufacturing mode. First, the influenci...
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Article
Open AccessOne-carbon metabolism factors and endometrial cancer risk
This is the largest prospective cohort analysis to assess how dietary factors involved in one-carbon metabolism are associated with endometrial cancer incidence, using 26 years of follow-up data from the Nurse...
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Article
Open AccessPRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage
p53 has a crucial role in governing cellular mechanisms in response to a broad range of genotoxic stresses. During DNA damage, p53 can either promote cell survival by activating senescence or cell-cycle arrest...
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Article
SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants