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Article
Molecular analysis of signaling events mediated by the cytoplasmic domain of leukemia inhibitory factor receptor α subunit
A chimeric receptor (130/190) containing the cytoplasmic region of leukemia inhibitory factor receptor α subunit (LIFRα, or gp190) and the extracellular transmembrane region of gp130 was generated. Expressed o...
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Article
A new clue for the pathogenesis of hepatitis C virus infection: Activation of the MAPK/ERK signaling initiated by envelope protein 2
Since cell signal transduction plays an important role in disclosing the nature of human diseases, the pathogenesis of viruses may result from the disturbance of intracellular signal cascades caused by viral p...
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Article
Involving of the cytoplasmic region of leukemia inhibitory factor receptor α subunit, IL-6 related signal transducer-gp130 or Fas death domain for MAPK p42/44 activation in HL-60 cell with LIF or anti-Fas IgG
The chimeric receptors were prepared by exchanging the cytoplasmic region between leukemia inhibitory factor (LIF) receptor α subunit (gp190) and the other subunit-gp130 (190/130,130/190) and separately transd...
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Article
Refolding of soluble leukemia inhibitory factor receptor fusion protein (gp 190 sol DAF) from urea
The insoluble inclusion bodies of soluble leukemia inhibitory factor receptor fusion protein (gp 190 sol DAF ) was solubilized in 8 M urea on the unfolding transitions, and several factors on the aggregate for...
