-
Article
Open AccessCandidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Olaparib (Lynparza™) is a PARP inhibitor approved for advanced BRCA-mutated (BRCAm) ovarian cancer. PARP inhibitors may benefit patients whose tumours are dysfunctional in DNA repair mechanisms unrelated to BRCA1...
-
Article
Open AccessThe outcomes of Perthes’ disease of the hip: a study protocol for the development of a core outcome set
Perthes’ disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardised outcomes makes comparisons between studie...
-
Article
Prospective ongoing prescribing error feedback to enhance safety: a randomised controlled trial
Prescribing errors are one of the most common adverse events in healthcare. Previous research in patient safety has highlighted the importance of error awareness education to enhance professional attitudes and...
-
Chapter
Lithium and Suicide Prevention
Over the past 40 years, a growing evidence base has established an association between lithium treatment and reduced rates of suicide in patients with mood disorders. This chapter examines the evidence surroun...
-
Article
Open AccessCommunity engagement to enhance trust between Gypsy/Travellers, and maternity, early years’ and child dental health services: protocol for a multi-method exploratory study
Gypsy/Travellers have poor health and experience discrimination alongside structural and cultural barriers when accessing health services and consequently may mistrust those services. Our study aims to investi...
-
Article
Open AccessThe effect of local repeated passive heating and handgrip exercise on reflex cutaneous vascular and sudomotor responses to whole-body heat stress
-
Article
The right ventricle following ultra-endurance exercise: insights from novel echocardiography and 12-lead electrocardiography
There is contradictory evidence related to the impact of ultra-marathon running on right ventricular (RV) structure and function. Consequently, the aims of this study were to: (1) comprehensively assess RV str...
-
Article
Effects of dawn simulation on markers of sleep inertia and post-waking performance in humans
To examine the effects of a simulated dawn during the last 30 min of sleep on the subsequent dissipation of sleep inertia and changes in simulated work and physical performance.
-
Article
Blood pressure regulation VII. The “morning surge” in blood pressure: measurement issues and clinical significance
In kee** with this review-series theme, we question whether the morning surge in blood pressure (MSBP) is a benign response to the physiological challenges during the first 3 h after waking, or is it clinica...
-
Article
Nutritional management and growth in children with chronic kidney disease
Despite continuing improvements in our understanding of the causes of poor growth in chronic kidney disease, many unanswered questions remain: why do some patients maintain a good appetite whereas others have ...
-
Article
Cancer patients’ and clinicians’ opinions on the best time in secondary care to approach patients for recruitment to longitudinal questionnaire-based research
A priority of the UK National Cancer Survivorship Initiative is to increase collection of patient-reported outcome measures (PROMs) longitudinally post-diagnosis. This study aimed to gather cancer patients’ an...
-
Article
Three Collaborative Models for Scaling Up Evidence-Based Practices
The current paper describes three models of research-practice collaboration to scale-up evidence-based practices (EBP): (1) the Rolling Cohort model in England, (2) the Cascading Dissemination model in San Die...
-
Article
Open AccessFeasibility test of a UK-scalable electronic system for regular collection of patient-reported outcome measures and linkage with clinical cancer registry data: The electronic Patient-reported Outcomes from Cancer Survivors (ePOCS) system
Cancer survivors can face significant physical and psychosocial challenges; there is a need to identify and predict which survivors experience what sorts of difficulties. As highlighted in the UK National Canc...
-
Article
Circadian variation in the circulatory responses to exercise: relevance to the morning peaks in strokes and cardiac events
Sudden cardiac and cerebral events are most common in the morning. A fundamental question is whether these events are triggered by the increase in physical activity after waking, and/or a result of circadian v...
-
Article
The acute post-exercise response of blood pressure varies with time of day
The reactivity of ambulatory blood pressure following a given change in everyday physical activities is highest in the morning. Whether the acute response of blood pressure following a controlled bout of steady-s...
-
Article
Is the magnitude of acute post-exercise hypotension mediated by exercise intensity or total work done?
The purpose of this study was to investigate the effects of exercise intensity on the magnitude of acute post-exercise hypotension while controlling for total work done over the exercise bout. Seven normotensi...
-
Chapter
Aimée, Jaguar and Sophie Scholl: Women on the German Home Front
This chapter focuses on Aimée & Jaguar (1999), a film adaptation of the best-selling book by Erica Fischer.1 Both the book and the film deal with the intimate relationship between Lilly Wust, a German wife and mo...
-
Article
Working together: local and global imperatives for women in Mongolia
Mongolia is a country in transition. Domestic violence has just begun to reach the public and political agenda, due in large part to the activism and lobbying of women’s groups within Mongolia. State attention...
-
Article
Ectomycorrhizal fungal biomass in roots and uptake of P from apatite by Pinus sylvestris seedlings growing in forest soil with and without wood ash amendment
Forest soil from an experimental Norway spruce forest with four levels of wood ash addition (0, 1, 3 and 6 tonnes ha−1) was used to inoculate pine (Pinus sylvestris) seedlings with indigenous ectomycorrhizal (EM)...
-
Article
Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers
Objective: To investigate the pharmacokinetics and tolerability of ZD1839 (Iressa™), an orally active selective epidermal growth factor receptor-tyrosine kinase inhibitor, in healthy volunteers.
