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Article
Effect of renal formic acid excretion on urinary calcium and ammonia concentrations
Intragastrically given formic acid (300 mg/kg) caused high urinary formate concentrations in rabbits with continuously decreasing urinary pH up to 30 h after the dose despite the fact that the bulk of the form...
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Article
Tellurium burden and neurochemical effects in moderate peroral exposure
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Article
Biochemical effects of methyl tertiary-butyl ether in extended vapour exposure of rats
Male Wistar rats exposed to 50, 100 or 300 ppm methyl tertiary-butyl ether vapour for 2–15 weeks, 6 h daily, 5 days a week, showed a dose-dependent blood ether concentration after 2 weeks' exposure. Blood concent...
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Article
Arsenic distribution and neurochemical effects in peroral sodium arsenite exposure of rats
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Article
Morpholine vapour inhalation and interactions of simultaneous nitrite intake
Male Wistar rats exposed intermittently to 300 ppm (12.5 μmol/l) morpholine vapour 5 days a week for 6 h daily during 4–15 weeks displayed an increasing brain solvent content analyzed by a sensitive gas chroma...
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Chapter and Conference Paper
Impaired Nerve Function in Rats After Prolonged Exposure to Vinyltoluene
Sixty male Wistar rats were exposed to vinyltoluene at 50, 100, or 300 ppm solvent concentrations 6 h daily, 5 days a week for up to 15 weeks. 20 control rats were similarly sham-exposed. Motor conduction velo...
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Chapter and Conference Paper
Neurotoxicity of Industrial Chemicals and Contaminants: Aspects of Biochemical Mechanisms and Effects
Nervous system toxicity by industrial chemicals and contaminants cannot be explained by a single mechanism because of the complex functional capacity of the brain and spinal cord. The nervous system is depende...
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Article
Dose-dependent effects of peroral dimethylformamide administration on rat brain
Three-month-old Wistar rats were given dimethylformamide in their drinking water at three concentrations. Succinate dehydrogenase activity decreased at the two higher doses in brain after 2 or 7 weeks. Decreas...
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Article
Neurochemical effects of short-term inhalation exposure to vinyltoluene vapor
Male rats were exposed to vinyltoluene vapor after pretreatment with polychlorinated biphenyl (PCB). Brain and body solvent burdens were in a linear relationship to the exposure level although it changed betwe...
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Article
Pharmacokinetics, pharmacodynamics and aspects of neurotoxic effects of four inhaled aliphatic chlorohydrocarbon solvents as relevant in man
Intermittent inhalation exposure of adult male rats to dichloromethane, trichloroethylene, 1,1,1-trichloroethane, perchloroethylene or to a combination of trichloroethylene and 1,1,1-trichloroethane for 5 days...
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Chapter and Conference Paper
Manganese-Induced Changes in Biotransformation Enzyme Activities in Rats
Human occupational manganese exposure is most usual in the mining industry (Rodier 1955; Sarić et al. 1977; Tanaka and Lieben 1969). In experimental animals chronic manganese intoxication can be induced by fee...
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Article
Neurochemical effects on rats ofn-heptane inhalation exposure
Inhalation exposure of male rats at three dose levels (4.2, 21, 62 mol/L) ton-heptane vapor caused a dose-dependent brain and body solvent burden, which increased during two weeks of exposure. Initial neurochemic...
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Article
Dose-dependent neurochemical changes during short-term inhalation exposure tom-xylene
Male Wistar rats were exposed tom-xylene vapor at concentrations of 2.0, 16.1, and 30.3 μmol/l for 2 weeks (5 days a week, 6 h daily). Xylene concentrations in brain and perirenal fat increased between weeks 1 an...
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Article
Cumulative biochemical effects of repeated subclinical hydrogen sulfide intoxication in mouse brain
Adult female NMRI mice exposed four times to 100 ppm hydrogen sulfide vapour for 2 h at 4-day intervals showed increasing inhibition of the cerebral cytochrome oxidase activity. Cerebral RNA decreased signific...
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Chapter and Conference Paper
Effects of Subacute Toluene Inhalation on its Metabolism and Disposition in Rat
Exposure of adult male rats to 300 ppm of toluene for 1 to 15 weeks 6 h daily caused accumulation of the solvent in brain and in perirenal fat. The body solvent content tended to decrease during extended expos...
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Article
Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake
Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly...
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Article
Trichloroethylene and 1,1,1-trichloroethane: effects on brain and liver after five days intermittent inhalation
The inhalation exposure of adult male rats to 7.9 μmol/l (200 ppm) of trichloroethylene for 4 days 6 h each day led to an accumulation of the solvent in the perirenal fat 17 h after the last exposure. Exposure...
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Article
CS2 binding to rat spinal neurofilaments
The binding of CS2 sulphur to rat spinal cord neurofilaments was studied 3 and 6 h after the intraperitoneal injection of 1.3 mmol of CS2 in control and phenobarbitone pretreated rats. The binding of CS2 carbon w...
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Article
High binding of CS2 sulphur in spinal cord axonal fraction
The binding of carbon disulphide sulphur was studied in the spinal cord and its axons of four control and four phenobarbitone pretreated adult rats 3 and 6 h after an intraperitoneal injection of 650 μmol of CS2 ...
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Article
The proteins of human myelin in inborn errors of metabolism and in chromosomal anomalies
The protein pattern of human brain myelin was investigated by means of horizontal polyacrylamide gel electrophoresis in four cases of different inborn errors of metabolism, in one case of Turner's syndrome, an...
