125 Result(s)

Article

First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

PIK3CA mutations are highly prevalent in solid tumors. Targeting phosphatidylinositol 3-kinase α is therefore an attractive strategy for treating cancers harboring PIK3CA mutations. Here, we report the results fr...

**ao-Li Wei, Fu-Rong Liu, Ji-Hong Liu, Hong-Yun Zhao, Yang Zhang… in Nature Communications (2022)

Article

In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

Cancer vaccine, which can promote tumor-specific immunostimulation, is one of the most important immunotherapeutic strategies and holds tremendous potential for cancer treatment/prevention. Here, we prepare a ...

Yuxin Guo, Shao-Zhe Wang, ** Zhang, Hao-Ran Jia, Ya-Xuan Zhu… in Nature Communications (2022)

Article

Evolution of defect structures leading to high ZT in GeTe-based thermoelectric materials

GeTe is a promising mid-temperature thermoelectric compound but inevitably contains excessive Ge vacancies hindering its performance maximization. This work reveals that significant enhancement in the dimensio...

Yilin Jiang, **feng Dong, Hua-Lu Zhuang, **cheng Yu, Bin Su… in Nature Communications (2022)

Article

Low-voltage ultrafast nonvolatile memory via direct charge injection through a threshold resistive-switching layer

The explosion in demand for massive data processing and storage requires revolutionary memory technologies featuring ultrahigh speed, ultralong retention, ultrahigh capacity and ultralow energy consumption. Al...

Yuan Li, Zhi Cheng Zhang, Jiaqiang Li, Xu-Dong Chen, Ya Kong… in Nature Communications (2022)

Article

Author Correction: Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen… in Nature Communications (2022)

Article

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcificati...

Zhen-**ng Wang, Zhong-Wei Luo, Fu-**ng-Zi Li, Jia Cao… in Nature Communications (2022)

Article

Author Correction: Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)

Cai-chun Liu, Jiao-long Chen, **ao-rong Chang, Qi-da He… in Scientific Reports (2022)

Article

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain

Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plas...

Rou-Gang **e, Wen-Guang Chu, Da-Lu Liu, Xu Wang, Sui-Bin Ma… in Nature Communications (2022)

Article

Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes

To investigate and identify first-trimester fasting plasma glucose (FPG) is related to gestational diabetes mellitus (GDM) and other adverse pregnancy outcomes in Shenzhen population.

Jia-Ning Tong, Lin-Lin Wu, Yi-Xuan Chen, **ao-Nian Guan, Fu-Ying Tian… in Endocrine (2022)

Article

Non-KREEP origin for Chang’e-5 basalts in the Procellarum KREEP Terrane

Mare volcanics on the Moon are the key record of thermo-chemical evolution throughout most of lunar history^1–3. Young mare basalts—mainly distributed in a region rich in potassium, rare-earth elements and phospho...

Heng-Ci Tian, Hao Wang, Yi Chen, Wei Yang, Qin Zhou, Chi Zhang, Hong-Lei Lin… in Nature (2021)

Article

Relationship between chronic kidney disease and sarcopenia

Few studies have investigated the relationship between sarcopenia and mild to moderate renal decline. This study aimed to investigate the relationship between chronic kidney disease (CKD) and sarcopenia. In to...

Ming-Dian Yu, Hui-Zhen Zhang, Yu Zhang, Sheng-** Yang, Miao Lin… in Scientific Reports (2021)

Article

The first competing risk survival nomogram in patients with papillary renal cell carcinoma

There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of...

**ng Su, Niu-Niu Hou, Li-Jun Yang, Peng-**ao Li, **ao-Jian Yang… in Scientific Reports (2021)

Article

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To characterize this pot...

Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen… in Nature Communications (2021)

Article

A Raman probe of phonons and electron–phonon interactions in the Weyl semimetal NbIrTe₄

There is tremendous interest in measuring the strong electron–phonon interactions seen in topological Weyl semimetals. The semimetal NbIrTe₄ has been proposed to be a Type-II Weyl semimetal with 8 pairs of opposi...

Iraj Abbasian Shojaei, Seyyedesadaf Pournia, Congcong Le… in Scientific Reports (2021)

Article

Reversible thermal regulation for bifunctional dynamic control of gene expression in Escherichia coli

Genetically programmed circuits allowing bifunctional dynamic regulation of enzyme expression have far-reaching significances for various bio-manufactural purposes. However, building a bio-switch with a post l...

Xuan Wang, Jia-Ning Han, Xu Zhang, Yue-Yuan Ma, Yina Lin… in Nature Communications (2021)

Article

Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A Correction to this paper has been published: https://doi.org/10.1007/s00125-020-03108-4.

**gyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi… in Nature (2021)

Article

X-ray flares from the stellar tidal disruption by a candidate supermassive black hole binary

Optical transient surveys have led to the discovery of dozens of stellar tidal disruption events (TDEs) by massive black hole in the centers of galaxies. Despite extensive searches, X-ray follow-up observation...

**nwen Shu, Wenjie Zhang, Shuo Li, Ning Jiang, Liming Dou… in Nature Communications (2020)

Article

A novel nomogram predicting the risk of positive biopsy for patients in the diagnostic gray area of prostate cancer

The roles played by several inflammatory factors in screening for prostate cancer (PCa) among gray area patients, namely those with serum prostate-specific antigen (PSA) levels between 4 and 10 ng/ml, have not...

Guang-Dong Hou, Yu Zheng, Wan-**ang Zheng, Ming Gao, Lei Zhang… in Scientific Reports (2020)

Article

Chromosome-level genome assembly of a parent species of widely cultivated azaleas

Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly for Rhododendron simsii, the primary ance...

Fu-Sheng Yang, Shuai Nie, Hui Liu, Tian-Le Shi, Xue-Chan Tian… in Nature Communications (2020)

Article

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. An effective preventive vaccine ...

**gyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi… in Nature (2020)