1,166 Result(s)
within
Internal Medicine
Oncology
Di** Xu
Medicine & Public Health
-
Article
Open AccessIdentification of lipid metabolism-related gene signature in the bone marrow microenvironment of multiple myelomas through deep analysis of transcriptomic data
Dysregulated lipid metabolism in the bone marrow microenvironment (BMM) plays a vital role in multiple myeloma (MM) development, progression, and drug resistance. However, the exact mechanism by which lipid me...
-
Article
Open AccessN6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, ...
-
Article
Open AccessLiver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis
Liver cancer (LC) is a prevalent malignancy and a leading cause of cancer-related mortality worldwide. Extensive research has been conducted to enhance patient outcomes and develop effective prevention strateg...
-
Article
Open AccessDNAJC1 facilitates glioblastoma progression by promoting extracellular matrix reorganization and macrophage infiltration
Glioblastoma (GBM) is a high-grade and heterogeneous subtype of glioma that presents a substantial challenge to human health, characterized by a poor prognosis and low survival rates. Despite its known involve...
-
Article
Open AccessPARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
By complexing poly (ADP-ribose) (PAR) in reaction to broke strand, PAR polymerase1 (PARP1) acts as the key enzyme participated in DNA repair. However, recent studies suggest that unrepaired DNA breaks results ...
-
Article
Open AccessPersonalized prediction of mortality in patients with acute ischemic stroke using explainable artificial intelligence
Research into the acute kidney disease (AKD) after acute ischemic stroke (AIS) is rare, and how clinical features influence its prognosis remain unknown. We aim to employ interpretable machine learning (ML) mo...
-
Article
Open AccessDevelo** a prognostic model for skin melanoma based on the persistent tumor mutation burden and determining IL17REL as a therapeutic target
One popular and well-established marker for the immune checkpoint blockade (ICB) response is tumor mutation burden (TMB). Persistent TMB (pTMB), a subset of TMB, provides a better indicator to predict patient ...
-
Article
Open AccessMutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3
Targeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited beneficiary populations and the emergence of drug resistance. This study inv...
-
Article
Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
-
Article
Open AccessChanges in nail position and antirotation blade angles on the risk of femoral head varus in PFNA fixed patients: a clinical review and comprehensive biomechanical research
Femoral head varus triggers poor clinical prognosis in intertrochanteric fracture patients with proximal femoral nail antirotation (PFNA) fixation. Studies present that changes in nail position and screw inser...
-
Article
Open AccessTumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...
-
Article
Open AccessDiagnostic yield of next-generation sequencing in suspect primary immunodeficiencies diseases: a systematic review and meta-analysis
To determine the diagnostic yield of Next-generation sequencing (NGS) in suspect Primary Immunodeficiencies Diseases (PIDs). This systematic review was conducted following PRISMA criteria. Searching Pubmed and...
-
Article
Open AccessInflammation accelerating intestinal fibrosis: from mechanism to clinic
Intestinal fibrosis is a prevalent complication of IBD that that can frequently be triggered by prolonged inflammation. Fibrosis in the gut can cause a number of issues, which continue as an ongoing challenge ...
-
Article
Open AccessSurvival trend and outcome prediction for pediatric Hodgkin and non-Hodgkin lymphomas based on machine learning
Pediatric Hodgkin and non-Hodgkin lymphomas differ from adult cases in biology and management, yet there is a lack of survival analysis tailored to pediatric lymphoma. We analyzed lymphoma data from 1975 to 20...
-
Article
Open AccessStrong evidence supports the use of estradiol therapy for the treatment of vaginal inflammation: a two-way Mendelian randomization study
Nowadays, there has been limited Mendelian randomization (MR) research focusing on the causal relationship between estradiol and vaginitis. Therefore, this study conducted a two-way MR study to clarify the cau...
-
Article
Open AccessMETTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
N6-methyladenosine (m6A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regulatory role in various aspects of RNA fate determination, such as mRNA stability, alternativ...
-
Article
Open AccessNF2: An underestimated player in cancer metabolic reprogramming and tumor immunity
Neurofibromatosis type 2 (NF2) is a tumor suppressor gene implicated in various tumors, including mesothelioma, schwannomas, and meningioma. As a member of the ezrin, radixin, and moesin (ERM) family of proteins,...
-
Article
Open AccessExploring prognostic values of DNA ploidy, stroma-tumor fraction and nucleoty** in stage II colon cancer patients
To assess the prognostic value of three novel biomarkers, DNA ploidy, stroma-tumor fraction, and nucleoty**, seeking for more accurate stratification in stage II colon cancer.
-
Article
Open AccessResearch on lncRNA CTBP1-DT as a potential therapeutic target to regulate cell function in colorectal cancer
Colorectal cancer, which originates from the human colon or rectum, is one of the leading causes of death worldwide. Timely diagnosis and interventional therapy can significantly improve the prognostic surviva...
-
Article
Open AccessA comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common primary liver cancer with a high incidence and mortality. Members of the growth-arresting-specific 2 (GAS2) family are involved in various biological processes in hum...
