28 Result(s)
within
Denise M. Scholtens
-
Article
Open AccessMixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based o...
-
Article
Open AccessSynuclein-γ (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease
Synuclein gamma (SNCG) expression is associated with advanced disease and chemoresistance in multiple solid tumors. Our goal was to determine if SNCG protein expression in ovarian cancer was correlated with cl...
-
Article
Genome-wide associations for birth weight and correlations with adult disease
Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlat...
-
Article
Nipple Aspirate Fluid Hormone Concentrations and Breast Cancer Risk
Prior reports identify higher serum concentrations of estrogens and androgens as risk factors for breast cancer, but steroids in nipple aspirate fluid (NAF) may be more related to risk. Incident breast cancer ...
-
Article
Genetics of Gestational Diabetes Mellitus and Maternal Metabolism
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy. Women with a history of GDM are at long-term risk for develo** type 2 diabetes (...
-
Article
Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1
Maternal glucose levels during pregnancy impact the develo** fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but littl...
-
Article
Open AccessHuman rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects
Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA met...
-
Article
Breast Ductal Lavage for Assessment of Breast Cancer Biomarkers
Lavage of the ductal systems of the breast provides fluid (ductal lavage fluid, DLF) containing hormones and products of hormone actions that may represent more accurately the composition of the breast than sa...
