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Article
Decreases in Pollutant Loading from Residual Soda Ash Production Waste
The attenuation of residual industrial loads of chloride (Cl-) and total ammonia (T-NH3) from Solvay waste bedsto Ninemile Creek, New York, and downstream polluted Onondaga Lake, is characterized and quantified b...
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Article
Patterns and impacts of inorganic tripton in Cayuga Lake
Inorganic tripton in the upper waters of Cayuga Lake, NY, is characterized, quantified and contrasted for shallow (<6 m) and deep (>100 m) water regions based on analyses with scanning electron microscopy equi...
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Article
Tripton, transparency and light penetration in seven New York reservoirs
Temporal patterns and inter-system differences in the attenuation coefficient for scalar irradiance (K s), Secchi disc transparency (SD), several measures of tripton, and chlorophyll a (Chl) are documented for th...
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Article
A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site
Bacteria expressing R67-plasmid encoded dihydrofolate reductase (R67 DHFR) exhibit high-level resistance to the antibiotic trimethoprim. Native R67 DHFR is a 34,000 Mr homotetramer which exists in equilibrium wit...
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Article
Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase
The bifunctional enzyme dihydrofolate reductase–thymidylate synthase catalyses both the reductive methylation of 2′–deoxyuridylate and the subsequent reduction of dihydrofolate to yield 2′–deoxythymidylate and...
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Chapter
Two Crystal Structures of Rat Liver Dyhydropteridine Reductase
Dihydropteridine reductase (DHPR EC 1.6.99.10) catalyzes the reduction of quinonoid dihydrobiopterin(qBH2) to tetrahydrobiopterin, using NADH as a cofactor. Tetrahydrobiopterin is a cofactor for the hydroxylating...
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Chapter
Inhibitor Binding to Thymidylate Synthase Is Mediated by Different Structural Determinants than Those That Promote Tight Binding to Dihydrofolate Reductase
Thymidylate synthase(TS) catalyzes the conversion of 2’deoxyuridylate(dUMP) to 2’deoxythymidylate(dTMP) utilizing the cofactor 5,10-methylenetetrahydrofolate(CH2-H4PteGlu) as both the single carbon donor and redu...
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Article
Verification of numerical model simulations of cumulus-environmental interaction in the high plains
Numerical model predictions of cumulus development over the high plains of Colorado are verified using aircraft and radar observations. Nine case examples are studied in detail, comparing natural and model pre...