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Global Conformational Constraint in the Design of a Grb2 SH2 Domain Inhibitor
Blockade of Grb2 SH2 domain binding involved in oncogenic signal transduction, may represent a new approach toward anticancer chemotherapeutics. For “pY-X-N” containing ligands, binding to Grb2 SH2 domains occ...
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Chapter
Local Conformational Constraint in the Design of a Grb2 SH2 Domain Inhibitor
Conformational constraint of amino acid side chains can be a powerful means of enhancing biological activity. For SH2 domains, where binding of peptide ligand is critically dependent on the interaction of phos...
