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  1. Article

    Open Access

    Impact of Tumor Burden on Normal Organ Distribution in Patients Imaged with CXCR4-Targeted [68Ga]Ga-PentixaFor PET/CT

    CXCR4-directed positron emission tomography/computed tomography (PET/CT) has been used as a diagnostic tool in patients with solid tumors. We aimed to determine a potential correlation between tumor burden and...

    Sebastian E. Serfling, Constantin Lapa, Niklas Dreher in Molecular Imaging and Biology (2022)

  2. Article

    Open Access

    Training on Reporting and Data System (RADS) for Somatostatin-Receptor Targeted Molecular Imaging Can Reduce the Test Anxiety of Inexperienced Readers

    For somatostatin receptor (SSTR)-positron emission tomography/computed tomography (PET/CT), a standardized framework termed SSTR-reporting and data system (RADS) has been proposed. We aimed to elucidate the im...

    Alexander Weich, Takahiro Higuchi, Ralph A. Bundschuh in Molecular Imaging and Biology (2022)

  3. Article

    Correction to: Value of PET imaging for radiation therapy

    Constantin Lapa, Ursula Nestle, Nathalie L. Albert in Strahlentherapie und Onkologie (2022)

  4. No Access

    Chapter

    Specific PET Tracers for Solid Tumors and for Definition of the Biological Target Volume

    This chapter provides an overview of the current status of positron emission tomography for definition of the biological target volume in a variety of solid tumors, i.e., brain tumors, squamous cell carcinomas...

    Constantin Lapa, Ken Herrmann in Image-Guided High-Precision Radiotherapy (2022)

  5. Article

    Open Access

    Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity – initial experience and comparison to [18F]FDG PET/CT and MRI

    While [18F]-fluorodeoxyglucose ([18F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake...

    Christian Linz, Roman C. Brands in European Journal of Nuclear Medicine and M… (2021)

  6. Article

    Value of PET imaging for radiation therapy

    This comprehensive review written by experts in their field gives an overview on the current status of incorporating positron emission tomography (PET) into radiation treatment planning. Moreover, it highlight...

    Constantin Lapa, Ursula Nestle, Nathalie L. Albert in Strahlentherapie und Onkologie (2021)

  7. Article

    Open Access

    Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients

    The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

    Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter in EJNMMI Research (2021)

  8. Article

    Open Access

    Thyroid incidentalomas with increased focal 18F-FDG uptake in 18F-FDG PET/CT of a patient with multiple primary cancers.

    Patrick W. Mihatsch, Matthias Beissert, Thorsten A. Bley, Andreas K. Buck in Endocrine (2021)

  9. No Access

    Article

    Nuklearmedizinische Theranostik

    Theranostische Verfahren bestimmen zunehmend die kombinierte diagnostische und therapeutische Patientenversorgung in der Nuklearmedizin. Drei neue theranostische Ansätze in unterschiedlichen klinischen Stadien...

    Matthias Eiber, Clemens Kratochwil, Constantin Lapa in Der Onkologe (2021)

  10. Article

    Open Access

    Intraindividual comparison of [177Lu]Lu-DOTA-EB-TATE and [177Lu]Lu-DOTA-TOC

    The radiolabelled somatostatin analogue [177Lu]Lu-DOTA-EB-TATE binds to albumin via Evans blue, thereby increasing the residence time in the blood and potentially allowing more therapeutic agent to be absorbed in...

    Heribert Hänscheid, Philipp E. Hartrampf in European Journal of Nuclear Medicine and M… (2021)

  11. Article

    Open Access

    Prognostic implications of dual tracer PET/CT: PSMA ligand and [18F]FDG PET/CT in patients undergoing [177Lu]PSMA radioligand therapy

    Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with 177Lu-labeled PSMA ligands has achieved remarkable results in advanced disease stages of metastatic castration-resistant prostate ...

    Kerstin Michalski, Juri Ruf, Christian Goetz in European Journal of Nuclear Medicine and M… (2021)

  12. Article

    Open Access

    [18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species

    Stem cell therapy holds great promise for tissue regeneration and cancer treatment, although its efficacy is still inconclusive and requires further understanding and optimization of the procedures. Non-invasi...

    Naoko Nose, Suguru Nogami, Kazuhiro Koshino, **nyu Chen in Scientific Reports (2021)

  13. Article

    Open Access

    Sarcoid-like reactions: a potential pitfall in oncologic imaging

    Selamawit Gebrekidan, Tina Schaller in European Journal of Nuclear Medicine and M… (2021)

  14. Article

    Open Access

    Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy

    [18F]fluorodeoxyglucose (FDG) PET and [123I]metaiodobenzylguanidine (MIBG) scintigraphy may contribute to the differential diagnosis of neurodegenerative parkinsonism. To identify the superior method, we retrospe...

    Joachim Brumberg, Nils Schröter, Ganna Blazhenets, Lars Frings in npj Parkinson's Disease (2020)

  15. Article

    Open Access

    Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging

    Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

    Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani in EJNMMI Physics (2020)

  16. Article

    Open Access

    Capabilities of multi-pinhole SPECT with two stationary detectors for in vivo rat imaging

    We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bo...

    Jan P. Janssen, Jan V. Hoffmann, Takayuki Kanno, Naoko Nose in Scientific Reports (2020)

  17. No Access

    Article

    False-negative 18F-PSMA-1007 PET/CT in metastatic prostate cancer related to high physiologic liver uptake

    Philipp E. Hartrampf, Anna Katharina Seitz in European Journal of Nuclear Medicine and M… (2020)

  18. Article

    Open Access

    Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

    The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also used in the therapeutic appl...

    **nyu Chen, Takashi Kudo, Constantin Lapa, Andreas Buck in Journal of Neural Transmission (2020)

  19. No Access

    Article

    Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake

    In this study, we aimed to quantitatively investigate the biodistribution of [18F]DCFPyL in patients with prostate cancer (PCa) and to determine whether uptake in normal organs correlates with an increase in tumo...

    Rudolf A. Werner, Ralph A. Bundschuh, Lena Bundschuh in Molecular Imaging and Biology (2020)

  20. No Access

    Article

    68Ga-PSMA I&T PET/CT for primary staging of prostate cancer

    The present study is based on a retrospective analysis of Gallium-68 (68Ga)-labelled prostate-specific membrane antigen (68Ga-PSMA I&T) PET/CT performed in newly diagnosed, treatment-naïve prostate cancer (PCa) p...

    Wojciech Cytawa, Anna Katharina Seitz in European Journal of Nuclear Medicine and M… (2020)

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