74 Result(s)
within
Chunfang **
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessA 14-gene gemcitabine resistance gene signature is significantly associated with the prognosis of pancreatic cancer patients
To identify a gemcitabine resistance-associated gene signature for risk stratification and prognosis prediction in pancreatic cancer. Pearson correlation analysis was performed with gemcitabine half maximal in...
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Article
Open AccessA therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Snakebite is a medical emergency causing high mortality and morbidity in rural tropical communities that typically experience delayed access to unaffordable therapeutics. Viperid snakes are responsible for the...
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Open AccessAnalysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge densit...
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Article
Open AccessEmpty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS
Amyotrophic lateral sclerosis (ALS) is a devastating incurable neurological disorder characterized by motor neuron (MN) death and muscle dysfunction leading to mean survival time after diagnosis of only 2–5 ye...
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Open AccessDesigned CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging. Soluble receptor-based strategies are not established for chemokine receptors due to their discontinuous architecture. Macro...
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Article
Open AccessmRNA and miRNA expression profile reveals the role of miR-31 overexpression in neural stem cell
A detailed understanding of the character and differentiation mechanism of neural stem cells (NSCs) will help us to effectively utilize their transplantation to treat spinal cord injury. In previous studies, w...
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Open AccessIn utero exposure to endogenous maternal polyclonal anti-Caspr2 antibody leads to behavioral abnormalities resembling autism spectrum disorder in male mice
The concept that exposure in utero to maternal anti-brain antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for over a decade. We determined that antibodies targ...
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Open AccessAdoptive transfer of bone marrow-derived dendritic cells (BMDCs) alleviates OVA-induced allergic airway inflammation in asthmatic mice
Airway dendritic cells (DCs) are recognized as important factors in the mechanisms of allergic inflammatory diseases. Suppressor of cytokine signaling 3 (SOCS3) is involved in regulating the functions of T cel...
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Open AccessAuthor Correction: The roles of p38 MAPK → COX2 and NF-κB → COX2 signal pathways in age-related testosterone reduction
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessObtaining elevation of Oncomelania Hupensis habitat based on Google Earth and it’s accuracy evaluation: an example from the Poyang lake region, China
Schistosomiasis japonicum is a major zoonosis that seriously harms human health and affects social and economic development in China. The control of Oncomelania Hupensis, the only intermediate host of schistosome...
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Open AccessPPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus
Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in adolescence, progressively worsening through the third to fourth decades of life. ...
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Open AccessAberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer
Breast cancer is one of the most common malignant cancers affecting females. Estrogen receptor (ER)-positive breast cancer is responsive to endocrine therapy. Although current therapies offer favorable prospec...
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Open AccessThe roles of p38 MAPK → COX2 and NF-κB → COX2 signal pathways in age-related testosterone reduction
In our study, we explored changes in the redox status and inflammatory response in the testes of the SAMP8 model of varying ages (2, 4, 8, 10 months old) compared with control mice SAMR1 by the methods of immu...
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Open AccessAuthor Correction: Multi-qubit Quantum Rabi Model and Multi-partite Entangled States in a Circuit QED System
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessSimulating Anisotropic quantum Rabi model via frequency modulation
Anisotropic quantum Rabi model is a generalization of quantum Rabi model, which allows its rotating and counter-rotating terms to have two different coupling constants. It provides us with a fundamental model ...
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Open AccessMulti-qubit Quantum Rabi Model and Multi-partite Entangled States in a Circuit QED System
Multi-qubit quantum Rabi model, which is a fundamental model describing light-matter interaction, plays an important role in various physical systems. In this paper, we propose a theoretical method to simulate...
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Open AccessAuthor Correction: Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessSelectively nitrogen-doped carbon materials as superior metal-free catalysts for oxygen reduction
Do** with pyridinic nitrogen atoms is known as an effective strategy to improve the activity of carbon-based catalysts for the oxygen reduction reaction. However, pyridinic nitrogen atoms prefer to occupy at...
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Open AccessPD-L1 expression in pleural effusions of pulmonary adenocarcinoma and survival prediction: a controlled study by pleural biopsy
PD-L1 expression in pleural effusions (PE) of lung adenocarcinoma (ADC) was compared with pleural biopsies and the positive expression in PE was correlated with survival time. The matched slices from same pati...
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Article
Open AccessAct1 is a negative regulator in T and B cells via direct inhibition of STAT3
Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases...
