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Open AccessCatalytic N-modification of α-amino acids and small peptides with phenol under bio-compatible conditions
The functionalization of α-amino acids and peptides provides the opportunity to tailor the properties of these biomolecules for diverse applications in chemistry and biology. Previous methods for N-modification i...
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Open AccessBi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints
Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has...
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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
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Conversion of Lignin into High Value Chemical Products
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Addendum: Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds
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Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds
Nucleophilic addition reactions of organometallic reagents to carbonyl compounds for carbon–carbon bond construction have played a pivotal role in modern chemistry. However, this reaction's reliance on petrole...
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Photo-induced iodination of aryl halides under very mild conditions
Aryl iodides are useful precursors in the synthesis of compounds used, for example, in the pharmaceutical and electronics industries. This protocol describes a transition metal–free, photo-induced aromatic Fin...
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Open AccessAlteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice
Spermatogenesis in adulthood depends on the successful neonatal establishment of the spermatogonial stem cell (SSC) pool and gradual differentiation during puberty. The stage-dependent changes in protein preny...
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Catalytic Grignard-Type Addition of Aryl C‐H Bonds to C=O and C=N Bonds
As an alternative to the classical Grignard reaction, transition-metal catalyzed direct addition of aryl C-H bonds to carbonyl groups and their analogues have recently attracted increasing attention due to its...
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Open AccessEGR1 regulates hepatic clock gene amplitude by activating Per1 transcription
The mammalian clock system is composed of a master clock and peripheral clocks. At the molecular level, the rhythm-generating mechanism is controlled by a molecular clock composed of positive and negative feed...
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Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides
Carboxylate as a promising and valuable directing group has attracted a great deal of attention. However, employing it as a traceless direction group has rarely been reported. We developed the ruthenium-cataly...
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Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water
Methods to assemble alkynes are essential for synthesizing fine chemicals, pharmaceuticals and polymeric photo-/electronic materials. Using light as a clean energy form and water as a green solvent has the pot...
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The Barbier–Grignard-type arylation of aldehydes using unactivated aryl iodides in water
Carbon–carbon bond formation is the essence of organic synthesis. One of the most important methods for forming carbon–carbon bonds is the Barbier–Grignard-type reaction, which was discovered over a century ag...
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Open AccessGGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to...
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Unorthodox chemistry for an unorthodox challenge: Exploration of new chemical reactivities for a sustainable future
The sustainable development of our future represents an unorthodox challenge in sciences and technologies. The exploration of unconventional chemical reactivities that could potentially result in more sustaina...
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β-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription
It is well accepted that cell scattering (dispersion of clustered cells into single cells) is the initial step of tumor metastasis, and the downregulation of E-cadherin is associated with metastatic potential ...
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Cross-Dehydrogenative Coupling Reactions of sp3-Hybridized C–H Bonds
New methodologies in cross-coupling reaction using C–H bonds as substrates is of great interest due to the challenges associated with C–H bond activation and the potential to streamline synthesis by the elimin...
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The association of CaM and Hsp70 regulates S-phase arrest and apoptosis in a spatially and temporally dependent manner in human cells
The cell cycle is controlled by regulators functioning at the right time and at the right place. We have found that calmodulin (CaM) has specific distribution patterns during different cell-cycle stages. Here,...
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Calmodulin regulates the post-anaphase reposition of centrioles during cytokinesis
A transient postanaphase repositioning of the centriole is found to control the completion of cytokinesis. Using a green fluorescent protein-calmodulin fusion protein as a living cell probe, we have previously...
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Water as a reaction medium for clean chemical processes
Solvent usage is often an integral part of manufacturing process, whether it is chemical or another industrial sector. Thus, this unavoidable choice of a specific solvent for a desired manufacturing process ca...
