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  1. No Access

    Chapter

    Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP

    Following exposure to environmental insults, the cells in most tissues dramatically increase the production of a group of proteins that are collectively known as “heat shock” or stress proteins (Parsell and Lindq...

    Shu-Bing Qian, Cam Patterson in Cell Stress Proteins (2007)

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    Article

    CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

    CHIP — a co-chaperone/ubiquitin ligase — not only targets chaperone substrates for degradation, but mediates Hsp70 turnover after misfolded substrates have been depleted. The sequential catalysis of the CHIP-a...

    Shu-Bing Qian, Holly McDonough, Frank Boellmann, Douglas M. Cyr, Cam Patterson in Nature (2006)

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    Protocol

    Cystic Fibrosis Transmembrane Conductance Regulator as a Model Substrate to Study Endoplasmic Reticulum Protein Quality Control in Mammalian Cells

    Components of the ubiquitin-proteasome system function on the surface of the endoplasmic reticulum (ER) to select misfolded proteins for degradation. Herein we describe methods that allow for the study of the ...

    J. Michael Younger, Chun-Yang Fan, Liling Chen… in Ubiquitin-Proteasome Protocols (2005)

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    Article

    Shear Stress Reduces Protease Activated Receptor-1 Expression in Human Endothelial Cells

    Shear stress has been shown to regulate several genes involved in the thrombotic and proliferative functions of endothelial cells. Thrombin receptor (protease-activated receptor-1: PAR-1) increases at sites of...

    Kytai Truong Nguyen, Suzanne G. Eskin, Cam Patterson… in Annals of Biomedical Engineering (2001)

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    Article

    The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

    To maintain quality control in cells, mechanisms distinguish among improperly folded peptides, mature and functional proteins, and proteins to be targeted for degradation. The molecular chaperones, including h...

    Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu… in Nature Cell Biology (2001)

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    Article

    The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

    The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient1,2,3,4. Most nascent CFTR is retained in th...

    Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger… in Nature Cell Biology (2001)

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    Article

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB (NF-κB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqui Han… in Molecular and Cellular Biochemistry (2000)

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    Chapter

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-кB (NF-кB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqi Han… in Control of Gene Expression by Catecholamin… (2000)

  9. No Access

    Article

    Genomic structure of the human KDR/flk-1 gene

    Li-Yan Yin, Yaxu Wu, Carol A. Ballinger, Cam Patterson in Mammalian Genome (1998)

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