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Article
In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies
Mice adoptively transferred with mouse B cells edited via CRISPR to express human antibody variable chains could help evaluate candidate vaccines and develop better antibody therapies. However, current editing...
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Article
Open AccessMolecular sieving of iso-butene from C4 olefins with simultaneous high 1,3-butadiene and n-butene uptakes
Iso-butene (iso-C4H8) is an important raw material in chemical industry, whereas its efficient separation remains challenging due to similar molecular properties of C4 olefins. The ideal adsorbent should possess ...
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Article
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia–reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway
Hypothermic machine perfusion (HMP) has been demonstrated to be more effective in mitigating ischemia–reperfusion injury (IRI) of donation after circulatory death (DCD) organs than cold storage (CS), yet the u...
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Article
Correction: ROR1-targeting switchable CAR-T cells for cancer therapy
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Article
Design of an active-source seismic detection system based on illumination analysis and migration imaging experiments: considering the Zhuxi mining area as an example
The purpose of this paper is to discuss the feasibility of utilizing the non-explosive source green seismic exploration technology to detect mineral resources in the deep of complex mountainous areas of wester...
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Article
Open AccessExpert Consensus on the Clinical Utilization of Ketamine and Its Isomers in Intensive Care Units
Analgesia and sedation are important treatment strategies in the intensive care unit (ICU). Due to the opioid crisis, opioid-sparing medications become the focus of clinical studies. Ketamine and its isomers (...
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Article
Identification of Motor Nuclei in the Medulla Oblongata of Carp for Biological Control
Brain-controlled technology is the key technology in biological control, and the corresponding relationship between animal brain nuclei and motor behavior is the core. The purpose of this study was to explore ...
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Article
Soft Label Guided Unsupervised Discriminative Sparse Subspace Feature Selection
Feature selection and subspace learning are two primary methods to achieve data dimensionality reduction and discriminability enhancement. However, data label information is unavailable in unsupervised learnin...
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Article
Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury
Cerebral ischemia–reperfusion injury (CIRI) leads to malignant brain edema, blood–brain barrier destruction, and neuronal apoptosis. N6-methyladenosine (m6A) RNA modification in CIRI was still limited explored...
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Article
Open AccessAn angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis
Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp...
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Article
Enhanced performance of EEG-based brain–computer interfaces by joint sample and feature importance assessment
Electroencephalograph (EEG) has been a reliable data source for building brain–computer interface (BCI) systems; however, it is not reasonable to use the feature vector extracted from multiple EEG channels and...
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Article
LKFormer: large kernel transformer for infrared image super-resolution
Given the broad application of infrared technology across diverse fields, there is an increasing emphasis on investigating super-resolution techniques for infrared images within the realm of deep learning. Des...
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Article
Galectin-3 Mediates Endotoxin Internalization and Caspase-4/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury
Besides being recognized by membrane receptor TLR4, lipopolysaccharide (LPS) can also be internalized into the cytosol and activate Caspase-4/11 pyroptotic pathways to further amplify inflammation in sepsis. T...
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Article
Thermal sensation prediction model for high-speed train occupants based on skin temperatures and skin wettedness
Passenger thermal comfort in high-speed train (HST) carriages presents unique challenges due to factors such as extensive operational areas, longer travel durations, larger spaces, and higher passenger capacit...
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Article
Open AccessBehavioral variant frontotemporal dementia associated with GRN and ErbB4 gene mutations: a case report and literature review
To report the clinical manifestation and genetic characteristics of a patient having frontotemporal dementia (FTD) with abnormal behavior and unstable walking.
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Article
Open AccessInteraction-selective molecular sieving adsorbent for direct separation of ethylene from senary C2-C4 olefin/paraffin mixture
Olefin/paraffin separations are among the most energy-intensive processes in the petrochemical industry, with ethylene being the most widely consumed chemical feedstock. Adsorptive separation utilizing molecul...
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Chapter and Conference Paper
Assessment of High-Speed Train Interactions with Containment Walls in Post-derailment Collisions
To protect high-speed trains in derailments, reinforced concrete (RC) derailment containment walls are often built beside the track. The resulting problem is that derailed trains hit the surrounding RC derailm...
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Chapter and Conference Paper
Research on X Ray Live Work of UHV Transmission Line by Helicopter
In this paper, an X ray device used in UHV helicopter live work is developed, and its electrical performance, mechanical performance and X ray detection function are tested. The results show that the feature o...
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Chapter and Conference Paper
Energy-Based Policy Constraint for Offline Reinforcement Learning
Offline RL suffers from the distribution shift problem. One way to address this issue is to constrain the divergence between the target policy and the behavior policy. However, directly using the behavior poli...
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Chapter and Conference Paper
Development and Validation of Moose Numerical Models for Vehicle Crash Safety Assessments
Moose-vehicle collisions often cause broken glass, deformed roofs, and dented hoods, which makes the driving space invaded to a large extent and seriously threatens the life safety of occupants, and is an esse...
