577 Result(s)
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Life Sciences
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Article
Tissue Accumulation, Cytotoxicity, Oxidative Stress, and Immunotoxicity in African Catfish, Clarias gariepinus Exposed to Sublethal Concentrations of Hexavalent Chromium
Hexavalent chromium (Cr6+) is one of the stable oxidation states of chromium that has been reported to elicit various toxic effects in aquatic organisms. However, the mechanisms of Cr6+ toxicity are still poorly ...
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Open AccessAssociation between the atherogenic index of plasma and hearing loss based on a nationwide cross-sectional study
Hearing loss (HL) is a worldwide public health issue for which the role of dyslipidemia has not been fully elucidated. This study aimed to use the atherogenic index of plasma (AIP), a well-established serum li...
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Open AccessConserved DNA sequence analysis reveals the phylogeography and evolutionary events of Akebia trifoliata in the region across the eastern edge of the Tibetan Plateau and subtropical China
The eastern edge of the Qinghai‒Tibet Plateau (QTP) and subtropical China have various regions where plant species originate and thrive, but these regions have been the focus of very few integrative studies. H...
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Open AccessHepatic Sirt6 activation abrogates acute liver failure
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...
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CD146, a therapeutic target involved in cell plasticity
Since its identification as a marker for advanced melanoma in the 1980s, CD146 has been found to have multiple functions in both physiological and pathological processes, including embryonic development, tissu...
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Open AccessA high heterozygosity genome assembly of Aedes albopictus enables the discovery of the association of PGANT3 with blood-feeding behavior
The Asian tiger mosquito, Aedes albopictus, is a global invasive species, notorious for its role in transmitting dangerous human arboviruses such as dengue and Chikungunya. Although hematophagous behavior is repu...
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Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. To dissect the spatiotemporal dynamics of DA release in both dens...
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Biogeographic patterns and drivers of soil viromes
Viruses are crucial in sha** soil microbial functions and ecosystems. However, studies on soil viromes have been limited in both spatial scale and biome coverage. Here we present a comprehensive synthesis of...
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Open AccessRBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation
Glioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance. Pharmacolog...
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Open AccessLINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4
Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but ...
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Open AccessMolecular adaptations underlying high-frequency hearing in the brain of CF bats species
The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for t...
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Open AccessAdaptive responses of erythritol-producing Yarrowia lipolytica to thermal stress after evolution
Elucidation of the thermotolerance mechanism of erythritol-producing Yarrowia lipolytica is of great significance to breed robust industrial strains and reduce cost. This study aimed to breed thermotolerant Y. li...
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Open AccessThe micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related...
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Open AccessDifferentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations
The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the precision medicine era and complete understanding of their genetic formation, admixture...
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Response of soil organic carbon stability and sequestration to long-term phosphorus application: insight from a 9-year field experiment in saline alkaline paddy soil
Phosphorus (P) addition is considered key factor in soil organic carbon (SOC) cycle. The potential impact mechanisms of P addition on SOC stability and sequestration were explored in saline-alkali soil.
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Morphological and physiological response of amphibious Rotala rotundifolia from emergent to submerged form
Rotala rotundifolia is an amphibious aquatic plant that can live in submerged and emergent forms. It is superior in nitrogen and phosphorus removal. To elucidate its adaptation strategies from emergent to submerg...
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Open AccessTargeted next-generation sequencing and long-read HiFi sequencing provide novel insights into clinically significant KLF1 variants
Krüppel-like factor 1 (KLF1), a crucial erythroid transcription factor, plays a significant role in various erythroid changes and haemolytic diseases. The rare erythrocyte Lutheran inhibitor (In(Lu)) blood gro...
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Differences of bacterioplankton communities between the source and upstream regions of the Yangtze River: microbial structure, co-occurrence pattern, and environmental influencing factors
The source area of the Yangtze River is located in the hinterland of the Qinghai-Tibet Plateau, which is known as the “Earth’s third pole.” It is the water conservation area and the natural barrier of the ecos...
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Responses of growth, yield and fruit quality of strawberry to elevated CO2, LED supplemental light, and their combination in autumn through spring greenhouse production
During the whole growth cycle growth, yield and fruit quality of strawberry are often strongly affected by insufficient CO2 and low light in greenhouse production. However, it is still not clear what extent growt...
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Association of Magnesium, Iron, Copper, and Zinc Levels with the Prevalence of Behavior Problems in Children and Adolescents
Magnesium (Mg), iron (Fe), copper (Cu), and zinc (Zn) are indispensable elements in children’s growth and development. However, epidemiological evidence regarding essential elements and their mixed exposure to...
