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Open AccessMicroRNA-106b is involved in transforming growth factor β1–induced cell migration by targeting disabled homolog 2 in cervical carcinoma
MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is an indispensable cytokine regulating the local microenvironment, th...
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Open AccessLack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PE...
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Correction: Corrigendum: TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
Nat. Immunol. 15, 676–686 (2014); published online 8 June 2014; corrected after print 21 August 2014 In the version of this article initially published, the labels along the horizontal axes of the graphs Figur...
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Open AccessMolecular profile of cochlear immunity in the resident cells of the organ of Corti
The cochlea is the sensory organ of hearing. In the cochlea, the organ of Corti houses sensory cells that are susceptible to pathological insults. While the organ of Corti lacks immune cells, it does have the ...
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Article
Open AccessThe synergistic effect of homocysteine and lipopolysaccharide on the differentiation and conversion of raw264.7 macrophages
Macrophages play pivotal roles in the progression of atherosclerosis (AS) and their heterogeneous differentiation patterns have been studied extensively. The classical subtype of activated macrophage, M1, prom...
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Open AccessComparative analysis of the alveolar macrophage proteome in ALI/ARDS patients between the exudative phase and recovery phase
Despite decades of extensive studies, the morbidity and mortality for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) remained high. Particularly, biomarkers essential for its early diagnosis ...
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Clonorchis sinensis: molecular cloning and functional expression of a novel cytosolic glutathione transferase
Glutathione transferases (GSTs) represent a large family of enzymes. In the high throughput sequencing of the cDNA library constructed from the adult stage of Clonorchis sinensis (Cs), we isolate another cDNA clo...
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Article
Molecular cloning and characterization of cDNA encoding a novel cytosolic glutathione transferase from Clonorchis sinensis
Glutathione transferases (GSTs) are a group of multifunction isoenzymes coded by many genes. A cDNA encoding a novel cytosolic GST enzyme was cloned from a Clonorchis sinensis (Cs) adult worm cDNA library by larg...