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Article
A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution
Nitric oxide synthase 3 (NOS3) produces the gasotransmitter nitric oxide (NO), which drives critical cellular signaling pathways by S-nitrosylating target proteins. Endogenous NOS3 resides at two distinct subcell...
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Article
Three functional variants were identified to affect RPS24 expression and significantly associated with risk of colorectal cancer
GWAS-identified 10q22.3 loci with lead SNP rs704017 are significantly associated with CRC risk in both Asian and European populations. However, the functional mechanism of this region is unclear. In this study...
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Chapter and Conference Paper
An Automated Online Spam Detector Based on Deep Cascade Forest
With the development of internet communication, spam is quite ubiquitous in our daily life. It not only disturbs users, but also cms. Although there exists many methods of spam detection in both the area of ...
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Article
Open AccessExome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
Germline coding variants have not been systematically investigated for pancreatic ductal adenocarcinoma (PDAC). Here we report an exome-wide investigation using the Illumina Human Exome Beadchip with 943 PDAC ...
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Article
Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma
Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma (ESCC). However, these common variants cannot explain all heritability of ESCC. Here w...
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Article
Determination of AR-42 enantiomeric purity by HPLC on chiral stationary phase
A sensitive and accurate liquid chromatographic method for the determination of AR-42 enantiomeric purity has been developed and validated. Baseline separation with a resolution higher than 1.9 was accomplishe...
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Article
Improved visible-light photocatalytic properties of ZnFe2O4 synthesized via sol-gel method combined with a microwave treatment
ZnFe2O4(ZFO) was synthesized via a sol-gel method firstly, then the ZFO was irradiated with microwave treatment to obtain M-ZFO using NH4Cl as dispersant for 10 min to improve the photocatalytic activity. Large p...
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Article
Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer
Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including breast. Androgen receptor (AR) coactivator ARA70, was first iden...