-
Article
Open AccessAge-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA patho...
-
Article
Challenges and advances on low-temperature rechargeable lithium-sulfur batteries
Lithium-sulfur (Li-S) batteries have demonstrated the potential to conquer the energy storage related market due to the extremely high energy density. However, their performances at low temperature are still n...
-
Article
Open AccessRectifying disorder of extracellular matrix to suppress urethral stricture by protein nanofilm-controlled drug delivery from urinary catheter
Urethral stricture secondary to urethral injury, afflicting both patients and urologists, is initiated by excessive deposition of extracellular matrix in the submucosal and periurethral tissues. Although vario...
-
Article
Open AccessSingle-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype
Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients wit...
-
Article
Open AccessMultiple founding paternal lineages inferred from the newly-developed 639-plex Y-SNP panel suggested the complex admixture and migration history of Chinese people
Non-recombining regions of the Y-chromosome recorded the evolutionary traces of male human populations and are inherited haplotype-dependently and male-specifically. Recent whole Y-chromosome sequencing studie...
-
Article
Open AccessTRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin ligase, tumour cell-intrinsic tripa...
-
Article
Flexible multibody dynamic analysis of shells with an edge center-based strain smoothing MITC method
In this study, a dynamic analysis method for flexible multibody systems using Reissner–Mindlin shells was developed, and an edge center-based strain smoothing mixed interpolation of tensorial components (MITC)...
-
Chapter and Conference Paper
Research on the Alarm Threshold for Steam Generator Tube Leak Monitoring of Small Modular Reactor
On the basis of fully learning from the existing principles of leak monitoring alarm thresholds setting of the steam generator tube in pressurized water reactor nuclear power plants, the principle of setting f...
-
Article
Risk of Erectile Dysfunction in Male Patients with Gout Treated with Febuxostat or Allopurinol: A Propensity Score-Matched Cohort Study
To evaluate and compare the risk of erectile dysfunction (ED) associated with the use of allopurinol and febuxostat in adult male gout patients.
-
Article
Open AccessImproved measurement of the strong-phase difference \(\delta _D^{K\pi }\) in quantum-correlated \(D{\bar{D}}\) decays
The decay \(D \rightarrow K^-\pi ^+\) D → ...
-
Article
Open AccessAssociation of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study
The interplay between physical activity (PA) and air pollution in relation to type 2 diabetes (T2D) remains largely unknown. Based on a large population-based cohort study, this study aimed to examine whether ...
-
Article
Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers
Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, ...
-
Article
Open AccessThe E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) plays a critical role in antiviral immunity and autoimmunity. The activity and stability of cGAS are fine-tuned by post-translational modifications. Here...
-
Article
Stem Hydraulic Traits are Decoupled from Leaf Ecophysiological Traits in Mangroves in Southern Philippines
The association between stem hydraulic traits and leaf functional traits in mangroves is unclear. We investigated the functional coordination between stem and leaf hydraulic traits and their integration with l...
-
Article
Open AccessComparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish
Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates. The Carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (C...
-
Article
Open AccessRegulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway
The upregulation of interferon (IFN)-stimulated genes induced by type I IFNs (namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early diagnosis and prediction of therapy re...
-
Article
Efficiently enhanced photoelectrochemical performance of TiO2 photoanode by facile drop-coating and calcination decoration of Bi4Ti3O12
We propose a simple method to prepare TiO2/Bi4Ti3O12 nanorod (TiO2/BTO NR) arrays for photoelectrochemical (PEC) water splitting. Compared with other complex processes, the Bi4Ti3O12 was directly decorated on the...
-
Article
Open AccessA new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses
Nanovaccines have shown the promising potential in controlling and eradicating the threat of infectious diseases worldwide. There has been a great need in develo** a versatile strategy to conveniently constr...
-
Article
Unequal relevance between different subtypes of fingernail psoriasis and psoriatic arthritis
Nail disease in psoriasis has been found to be associated with psoriatic arthritis (PsA); however, which subtype of nail disease holds greater relevance to PsA remains unclear. This study was performed to expl...
-
Article
Open AccessDietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA
Folic acid, served as dietary supplement, is closely linked to one-carbon metabolism and methionine metabolism. Previous clinical evidence indicated that folic acid supplementation displays dual effect on canc...
