60 Result(s)
within
Biomedicine, general
Pharmacology/Toxicology
**ng-hua Li
-
Article
Application of RT-PCR in formalin-fixed and paraffin-embedded lung cancer tissues
To analyze gene expression in formalin-fixed, paraffin-embedded lung cancer tissues using modified method.
-
Article
Improvement of mechanical heart function by trimetazidine in db/db mice
To investigate the influence of trimetazidine, which is known to be an antioxidant and modulator of metabolism, on cardiac function and the development of diabetic cardiomyopathy in db/db mouse.
-
Article
Mast cell degranulation induced by chlorogenic acid
To investigate the mechanism of chlorogenic acid (CA)-induced anaphylactoid reactions.
-
Article
Endothelial dysfunction induced by antibodies against angiotensin AT1 receptor in immunized rats
To investigate the association between autoantibodies against angiotensin AT1 receptor (AT1-AAs) and endothelial dysfunction in vivo.
-
Article
Attenuated Salmonella typhimurium carrying shRNA-expressing vectors elicit RNA interference in murine bladder tumors
To examine whether attenuated Salmonella typhimurium (S typhimurium) could be used as an anti-cancer agent or a tumor-targeting vehicle for delivering shRNA-expressing pDNA into cancer cells in a mouse tumor mode...
-
Article
Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury
Brain ischemia is a leading cause of death and long-term disabilities worldwide. Unfortunately, current treatment is limited to thrombolysis, which has limited success and a potential side effect of intracereb...
-
Article
Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model
To investigate the effects of piperine, a major pungent alkaloid present in Piper nigrum and Piper longum, on the tumor growth and metastasis of mouse 4T1 mammary carcinoma in vitro and in vivo, and elucidate the...
-
Article
Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring
Myostatin gene is a member of the transforming growth factor-β (TGF-β) family that negatively regulates skeletal muscle growth. Genetic polymorphisms in Myostatin were found to be associated with the peak bone mi...
-
Article
Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE−/− mice possibly via activated STAT3-mediated upregulation of tristetraprolin
To investigate the effects of the major component of high-density lipoprotein apolipoprotein A-I (apoA-I) on the development of atherosclerosis in LPS-challenged ApoE−/− mice and the underlying mechanisms.
-
Article
Stem cells and small molecule screening: haploid embryonic stem cells as a new tool
Stem cells can both self-renew and differentiate into various cell types under certain conditions, which makes them a good model for development and disease studies. Recently, chemical approaches have been wid...
-
Article
Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production
To investigate the effects and underlying mechanisms of 118, a novel derivative of mycophenolic acid, in a murine allogeneic skin graft model.
-
Article
A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth
To identify the contribution of individual isoform (α, β, γ, δ) of class I PI3Ks to tumor cell growth for proper use of PI3K inhibitors in cancer therapy.
-
Article
Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro
(±)Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective bindin...
-
Article
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation
To investigate the action of isothiafludine (NZ-4), a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus (HBV) in vitro and in vivo.
-
Article
A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients
To develop a population pharmacokinetic (PopPK) model of tacrolimus in healthy Chinese volunteers and liver transplant recipients for investigating the difference between the populations, and for potential ind...
-
Article
Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy
SM934 is a novel water-soluble artemisinin derivative with immunoregulatory activities that has been used to treat murine lupus nephritis. In the current study, we investigated the effects of SM934 on rat expe...
-
Article
Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation
Interferon-γ inducible protein 16 (IFI16), a DNA sensor for DNA double-strand break (DSB), is expressed in most human hepatocellular carcinoma cell (HCC) lines. In this study we investigated the re-localizatio...
-
Article
Liraglutide reduces the body weight and waist circumference in Chinese overweight and obese type 2 diabetic patients
To investigate the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor activator, on body weight and waist circumference in Chinese overweight and obese type 2 diabetic patients.
-
Article
Anti-tumor activities of active ingredients in Compound Kushen Injection
Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natu...
-
Article
Wogonin suppresses osteopontin expression in adipocytes by activating PPARα
Wogonin (5,7-dihydroxy-8-methoxyflavone), a major bioactive compound of the flavonoid family, is commonly extracted from the traditional Chinese medicine Scutellaria baicalensis and possesses antioxidant and anti...
