290 Result(s)

Article

The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling

DUSP22 is a dual-specificity phosphatase that inhibits T cell activation by inactivating the kinase Lck. Here we show that the E3 ubiquitin ligase UBR2 is a positive upstream regulator of Lck during T-cell act...

Ying-Chun Shih, Hsueh-Fen Chen, Chia-Ying Wu, Yi-Ru Ciou… in Nature Communications (2024)

Article

Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) play crucial roles in supporting hematopoiesis and hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we...

Jia Cao, Ling **, Zi-Qi Yan, **ao-Kai Wang, You-You Li, Zun Wang… in Nature Communications (2023)

Article

Ground-state electron transfer in all-polymer donor:acceptor blends enables aqueous processing of water-insoluble conjugated polymers

Water-based conductive inks are vital for the sustainable manufacturing and widespread adoption of organic electronic devices. Traditional methods to produce waterborne conductive polymers involve modifying th...

Tiefeng Liu, Johanna Heimonen, Qilun Zhang, Chi-Yuan Yang… in Nature Communications (2023)

Article

D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia

The hypothesis of N-methyl-D-aspartate receptor (NMDAR) dysfunction for cognitive impairment in schizophrenia constitutes the theoretical basis for the translational application of NMDAR co-agonist D-serine or...

**ao-Qin Zhang, Le Xu, **n-Yi Zhu, Zi-Hang Tang, Yi-Bei Dong… in Nature Communications (2023)

Article

Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....

Ting-Ting Gong, Shuang Guo, Fang-Hua Liu, Yun-Long Huo, Meng Zhang… in Nature Communications (2023)

Article

Epidemiological characteristics and temporal-spatial clustering analysis on human brucellosis in Jiangsu Province, 2006–2021

The marked increase in the incidence rate of brucellosis is a serious public health concern in Jiangsu Province. However, its temporal and spatial distribution has not been studied in depth. The main purpose o...

Nan Zhang, **n-yu Fang, Wei-zhong Zhou, Zhong-ming Tan, Shu-yi Liang… in Scientific Reports (2023)

Article

Tailoring chemical composition of solid electrolyte interphase by selective dissolution for long-life micron-sized silicon anode

Micron-sized Si anode promises a much higher theoretical capacity than the traditional graphite anode and more attractive application prospect compared to its nanoscale counterpart. However, its severe volume ...

Yi-Fan Tian, Shuang-Jie Tan, Chunpeng Yang, Yu-Ming Zhao… in Nature Communications (2023)

Article

Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion

Previous studies have speculated that brain activity directly controls immune responses in lymphoid organs. However, the upstream brain regions that control lymphoid organs and how they interface with lymphoid...

Dong-Dong Shi, Ying-Dan Zhang, Sen Zhang, Bing-Bing Liao… in Nature Communications (2023)

Article

Neuro-inspired optical sensor array for high-accuracy static image recognition and dynamic trace extraction

Neuro-inspired vision systems hold great promise to address the growing demands of mass data processing for edge computing, a distributed framework that brings computation and data storage closer to the source...

Pei-Yu Huang, Bi-Yi Jiang, Hong-Ji Chen, Jia-Yi Xu, Kang Wang… in Nature Communications (2023)

Article

Relationship between body composition and pulmonary function in the general population—a cross-sectional study in Ningxia

Studies considering the relationship between non-obesity-related body composition and lung function are few; therefore, this study aimed to explore these correlations and effects. This cross-sectional study co...

Yang-yang Pi, Wen-xuan Hu, Zi-ming Jiao, Peng-yi Hou, Yu-hong Zhang… in Scientific Reports (2023)

Article

A radiomics model based on magnetic resonance imaging to predict cytokeratin 7/19 expression and liver fluke infection of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC with liver fluke infection could harbor unique biological behaviors. This study was aimed at investigating radiomics features...

Jun-Qi Liu, **g Wang, **a-Ling Huang, Tian-Yi Liang, **n Zhou… in Scientific Reports (2023)

Article

Immunological characterization and diagnostic models of RNA N6-methyladenosine regulators in Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia, and it displays both clinical and molecular variability. RNA N6-methyladenosine (m6A) regulators are involved in a wide range of essential cellu...

Yuan Hui, Qi Ma, Xue-Rui Zhou, Huan Wang, Jian-Hua Dong, Li-Na Gao… in Scientific Reports (2023)

Article

Ce-mediated molecular tailoring on gigantic polyoxometalate {Mo₁₃₂} into half-closed {Ce₁₁Mo₉₆} for high proton conduction

Precise synthesis of polyoxometalates (POMs) is important for the fundamental understanding of the relationship between the structure and function of each building motif. However, it is a great challenge to re...

Xue-**n Li, Cai-Hong Li, Ming-Jun Hou, Bo Zhu, Wei-Chao Chen… in Nature Communications (2023)

Article

Effects of early aquatic exercise intervention on trunk strength and functional recovery of patients with lumbar fusion: a randomized controlled trial

This study investigated the effectiveness of an early aquatic exercise program on trunk muscle function and functional recovery of patients with lumbar fusion. Twenty-eight subjects were divided into two equal...

An-Hua Huang, Wen-Hsiang Chou, Wendy Tzyy-Jiuan Wang, Wen-Yin Chen… in Scientific Reports (2023)

Article

The effects of IL-1β stimulated human umbilical cord mesenchymal stem cells on polarization and apoptosis of macrophages in rheumatoid arthritis

Macrophages play an important role in the pathogenesis of rheumatoid arthritis (RA), in which the functions of pro-inflammatory macrophages (M1) and anti-inflammatory macrophages (M2) are different. Our previo...

Ying-Xuan Zeng, Kuang-Yi Chou, Jeng-Jong Hwang, Hwai-Shi Wang in Scientific Reports (2023)

Article

The effectiveness of optimal exercise-based strategy for patients with hip fracture: a systematic review and Bayesian network meta-analysis

The implementation of exercise intervention (EI) presents a promising and economical way for patients with hip fracture. However, the optimal type of EI remains unclear. The objective of this study is to evalu...

Rong-jia Pan, Si-jie Gui, Yu-Lian He, Fang Nian, **ao-Yan Ni… in Scientific Reports (2023)

Article

Diploid and tetraploid genomes of Acorus and the evolution of monocots

Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...

Liang Ma, Ke-Wei Liu, Zhen Li, Yu-Yun Hsiao, Yiying Qi, Tao Fu… in Nature Communications (2023)

Article

Visualizing the multi-level assembly structures of conjugated molecular systems with chain-length dependent behavior

It remains challenging to understand the structural evolution of conjugated polymers from single chains to solvated aggregates and film microstructures, although it underpins the performance of optoelectrical ...

Yang-Yang Zhou, Yu-Chun Xu, Ze-Fan Yao, Jia-Ye Li, Chen-Kai Pan… in Nature Communications (2023)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)