20,873 Result(s)
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English
Cancer Research
**hu Li
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Article
Site-dependence of invasiveness of ECA109 human oesophageal carcinoma cells in nude mice
ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron micro...
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Article
Identification of anthracycline analogues with enhanced cytotoxicity and lack of cross-resistance to adriamycin using a series of mammalian cell lines in vitro
Clinical resistance to adriamycin (ADR) develops readily, and cardiotoxicity is a major dose-limiting side effect. A range of anthracycline derivatives have been synthesized recently, and a number reported to ...
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Article
Clinical pharmacolinetics of 9, 10-anthracenedicarboxaldehyde-bis [(4,5-dihydro-1H-imidazol-2-yl)hydrazone]dihydrochloride
We studied the clinical pharmacokinetics of the anthracene derivative bisantrene using high-performance liquid chromatographic analysis. We administered the drug to ten patients at 120–250 mg/m2 IV; one of these ...
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Article
Clinical pharmacology of intracarotid etoposide
Pharmacokinetics studies were performed in ten patients who received VP-16 by intracarotid infusion at 100–300 mg/m2. VP-16 was analyzed by high-pressure liquid chromatography. ESTRIP and NONLIN were used to char...
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Article
Clinical pharmacology of 4-demethoxydaunorubicin (DMDR)
DMDR, a daunorubicin derivative with a higher therapeutic index and lower cardiotoxicity than either the parent drug or doxorubicin, is active when given PO in experimental animals. We studied its pharmacokine...
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Article
Pancreatic exocrine enzymes during the neonatal period in postmature rats
Pancreatic content of exocrine enzymes in newborn rat pups shows a sharp decline soon after birth. To investigate if this decline is a preprogrammed and, therefore, inherently controlled phenomenon, or a resul...
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Article
Lung cancer and prior tuberculosis infection in Shanghai
In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, ad...
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Article
High malic enzyme activity in tumor cells and its cross-reaction with antipigeon liver malic enzyme serum
Rabbit antibodies against pigeon liver malic enzyme (EC 1.1.1.40) were prepared. The antiserum gave single precipitation line with crude pigeon liver extract. Cross reaction was observed with partially purifie...
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Article
Pharmacokinetics of homoharringtonine in dogs
We studied the pharmacokinetics and distribution of homoharringtonine (HHT), an antitumor alkaloid, in anesthetized dogs using chromatographic and radiochemical techniques. Uniformly tritiated HHT was administ...
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Article
Template specificities of Aclacinomycin B on the inhibition of DNA-dependent RNA synthesis in vitro
The effect of Aclacinomycin B (ACM-B), an anthracycline antitumor antibiotic, on the DNA-dependent RNA synthesis using single- and double-stranded DNAs of known base content and sequence is studied. The data s...
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Article
Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells
C-1027, a new macromolecular peptide antitumor antibiotic produced by aStreptomyces strain, was extremely cytotoxic to cultured cancer cells and markedly inhibited the growth of transplantable tumors in mice. As ...
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Article
Age-related decrease of pulmonary metastasis of rat mammary carcinoma by activated natural resistance
We found that the number of pulmonary metastatic foci of spontaneously developed rat mammary carcinoma (SST-2), when transplanted subcutaneously in spontaneously hypertensive (SH) rats, decreased with aging.
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Article
Absence of H-ras point mutation at codon 12 inN-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat
In order to assess the possibility that activatedras-associated hepatic carcinomas might be much rarer in rats than mice because of the more frequent or rapid occurrence of powerful carcinogenic event(s) other th...
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Article
Effect of dietary vitamin E on the development of altered hepatic foci and hepatic tumors induced by the peroxisome proliferator ciprofibrate
The purpose of this study was to determine the effect of the dietary antioxidant vitamin E on hepatocarcinogenesis by peroxisome proliferators which, it is hypothesized, induce tumors by increased production o...
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Article
Quantitation of plasma membrane fatty acid-binding protein by enzyme dilution and monoclonal antibody based immunoassay
A plasma membrane fatty acid-binding protein (h-FABPPm) has been isolated from rat hepatocytes. Analogous proteins have also been identified in adipocytes, jejunal enterocytes and cardiac myocytes, all cells w...
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Article
The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology
The cytotoxicity of ara-C is believed to result from incorporation of ara-CTP into DNA and inhibition of DNA synthesis. Since complete inhibition of DNA synthesis would prevent further incorporation of ara-CTP...
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Chapter and Conference Paper
Stable Expression of Human HSP70 Gene in Rodent Cells Confers Thermal Resistance
When exposed to a non lethal heat shock, a variety of organisms and cell lines acquire a transient resistance to one or more subsequent exposures at elevated temperatures (Gener and Schneider, 1975; Henle and ...
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Article
Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer
An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung can...
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Article
Transcriptional effect of aflatoxin B1 on cytosine and/or hypoxanthine containing DNAs
The effect of aflatoxin Bt (AFB,) on the template function for RNA synthesis of several single and double-stranded synthetic DNAs containing cytosine (C) and/or hypoxanthine (H) bases is studied in vitro. The res...
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Article
Molecular control of myogenesis: antagonism between growth and differentiation
Insight into the molecular mechanisms that control establishment of the skeletal muscle phenotype has recently been obtained through cloning of a family of muscle-specific regulatory factors that can activate ...
