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**hu Li
Life Sciences
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Article
Metabolic engineering of Saccharomyces cerevisiae for high-level production of (+)-ambrein from glucose
(+)-Ambrein is the primary component of ambergris, a rare product found in sperm whales (Physeter microcephalus). Microbial production using sustainable resources is a promising way to replace animal extraction a...
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Quantifying corn LAI using machine learning and UAV multispectral imaging
Predicting leaf area index (LAI) is essential for understanding crop growth status and water-fertilizer management. The aim of this study was to evaluate the effectiveness of unmanned aerial vehicle (UAV) mult...
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Correction: Effects of the daily light-dark cycle on rhythms of behavior and physiology in boring giant clam Tridacna crocea
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Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC
Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular disorders, such as coronary heart disorder, hypertension, and cardiomyopathy. Cardiac fibroblast trans-differentiation i...
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Open AccessMulticenter proteome-wide Mendelian randomization study identifies causal plasma proteins in melanoma and non-melanoma skin cancers
This study addresses the diagnostic and therapeutic challenges in malignant melanoma (MM) and non-melanoma skin cancers (NMSC). We aim to identify circulating proteins causally linked to MM and NMSC traits usi...
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The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by a constant incidence rate. Unfortunately, effective pharmacological treatments for this condition are lacking and the ident...
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Open AccessDietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens
Liver lipid dysregulation is one of the major factors in the decline of production performance in late-stage laying hens. Silymarin (SIL), a natural flavonolignan extracted from milk thistle, is known for its ...
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Open AccessGPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
Acetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116) is an important homeostatic maintenance molecule in the body, but litt...
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Open AccessIL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...
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Open AccessBiogeographical distribution and community assembly of Myxococcota in mangrove sediments
Myxococcota, characterized by their distinct social lifestyles, are widely distributed micro-predators in global sediments. They can feed on a wide range of bacterial, archaeal, and fungal prey. Myxococcota ar...
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Mass spectrometry-based proteomic landscape of rice reveals a post-transcriptional regulatory role of N6-methyladenosine
Rice is one of the most important staple food and model species in plant biology, yet its quantitative proteomes are largely uncharacterized. Here we quantify the relative protein levels of over 15,000 genes a...
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Open AccessNeutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...
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Transcriptome analysis reveals the role of temperature in seed germination of Idesia polycarpa Maxim through the integration of phytohormones and sugar metabolism
The germination of Idesia polycarpa Maxim seeds plays a critical role in successfully cultivating this dioecious species. In order to reveal the mechanisms regulating the germination of I. polycarpa seeds under v...
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME...
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Open AccessHeritability of functional gradients in the human subcortico-cortical connectivity
The human subcortex plays a pivotal role in cognition and is widely implicated in the pathophysiology of many psychiatric disorders. However, the heritability of functional gradients based on subcortico-cortic...
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Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia
The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8+ T cell exhaustion results in reduced effectiveness of T cell-mediated immunity, thereby contributing to disease progressi...
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Open AccessTRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF receptor-associated factor 6 (TRAF6) is associated with multiple inflammatory disea...
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Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Novel recycling strategy for distillers’ grains waste: prolonged biochar aging promotes cadmium immobilization and lettuce growth by regulating soil nutrient availability and bacterial composition
Converting distillers’ grains (DGs) into biochar (BC) is sustainable option for waste-recycling, but how different aging times and application rates DG-derived BC (DG-BC) influenced lettuce growth and cadmium ...
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Open AccessBiological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumo...
