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Article
Open AccessThe efficacy and safety of adding PD-1 blockade to induction chemotherapy and concurrent chemoradiotherapy (IC-CCRT) for locoregionally advanced nasopharyngeal carcinoma: an observational, propensity score-matched analysis
Despite the success of PD-1 blockade in recurrent/metastatic nasopharyngeal carcinoma (NPC), its effect for locoregionally advanced NPC (LANPC) remains unclear. This study aimed to evaluate the benefit of addi...
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Article
Amorphous Sb/C composite with isotropic expansion property as an ultra-stable and high-rate anode for lithium-ion batteries
Antimony (Sb) is an intriguing anode material for Li-ion batteries (LIBs) owing to its high theoretical capacity of 660 mAh·g−1 and appropriate working potential of ~ 0.8 V (vs. Li+/Li). However, just like all al...
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Article
Nanodiamond: a promising metal-free nanoscale material in photocatalysis and electrocatalysis
Benefiting from its surface-rich functional groups, eco-friendliness, impressive electrochemical properties, excellent light absorption, structural tunability at the atomic/morphological level, and ultra-high ...
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Article
Open AccessDEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis
The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with cell senescence. Differentiated em...
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Article
Open AccessWild-type IDH2 is a therapeutic target for triple-negative breast cancer
Mutations in isocitrate dehydrogenases (IDH) are oncogenic events due to the generation of oncogenic metabolite 2-hydroxyglutarate. However, the role of wild-type IDH in cancer development remains elusive. Her...
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Article
Microstructure and mechanical properties of Co-28Cr-6Mo-0.22C investment castings by current solution treatment
This study examined the impact of current solution treatment on the microstructure and mechanical properties of the Co-28Cr-6Mo-0.22C alloy investment castings. The findings reveal that the current solution tr...
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Article
Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
The mechanisms underlying major depressive disorder (MDD) in children and adolescents are unclear. Metabolomics has been utilized to capture metabolic signatures of various psychiatric disorders; however, urin...
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Article
Phosphorus additives driving the bacterial community succession during Bacillus spp. remediation of the uranium tailings
Uranium tailings discharged into uranium tailings ponds could generate environmental pollution issues. Microbial-induced phosphate mineralization could reduce the release of uranium, in turn effectively managi...
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Article
A hypoxic pyrolysis process to turn petrochemical sludge into magnetic biochar for cadmium-polluted soil remediation
Biochar has been considered as a promising material for soil remediation, particularly for its ability to reduce the bioavailability of cadmium (Cd) in soil through sorption. However, long-term remediation may...
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Article
O2 adsorption on Fe3O4 (110) surface and effect of gangue element Al do**: combined study of binding experiment and ab initio molecular dynamics
At high temperature, the chemical reaction mechanism at the interface of magnetite and the influence mechanism of gangue element Al on the oxidation performance of magnetite are not clear. In addition, due to ...
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Article
Open AccessEffect of endoscopic therapy and drug therapy on prognosis and rebleeding in patients with esophagogastric variceal bleeding
Esophagogastric variceal bleeding (EVB) is one of the common digestive system emergencies with poor prognosis and high rate of rebleeding after treatment. To explore the effects of endoscopic therapy and drug ...
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Article
Open AccessThriving at work as a mediator of the relationship between psychological resilience and the work performance of clinical nurses
This study aims to investigate the relationship between psychological resilience, thriving at work, and work performance among nurses, as well as analyse the mediating role of thriving at work in the relations...
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Article
Open AccessPostoperative hyper-inflammation as a predictor of poor outcomes in patients with acute type A aortic dissection (ATAAD) undergoing surgical repair
Postoperative hyper-inflammation is a frequent event in patients with acute Stanford type A aortic dissection (ATAAD) after surgical repair. This study's objective was to determine which inflammatory biomarker...
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Article
Open AccessIdentification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, pro...
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Article
Open AccessEffects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions have emerged as promising adjunctive treatment strategies not ...
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Article
A seismic response prediction method based on a self-optimized Bayesian Bi-LSTM mixed network for high-speed railway track-bridge system
The construction of China’s high-speed railway (HSR) network has reached earthquake-prone regions, necessitating a timely and accurate post-disaster quick prediction approach to ensure the safety of the HSR sy...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Interface interaction between SiO2 and magnetite under high temperature: particle migration and inhibition mechanism
Silicon is one of the main gangue components in iron ore, usually in the form of quartz and olivine. Numerous studies have shown that SiO2 has a two-sided effect on the consolidation of pellets during high-temper...
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Article
Open AccessCorrelation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis
Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was ...
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Article
Open AccessHMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis
Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...
