140 Result(s)
within
**g-Han Li
Life Sciences
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Article
Genome-wide signatures of the geographic expansion and breeding of soybean
Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We anal...
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The effects of environmental, climatic and spatial factors on diatom diversity in Sphagnum peatlands in central and northeastern China
Peatlands are limno-terrestrial habitats that support rich microscopic algae, whereas algal distribution is poorly known in peaty environments. This study aims to explore diatom diversity patterns and underlyi...
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Article
Open AccessBiparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report ...
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Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Open AccessIdentification of fish species through tRNA-based primer design
The correct establishment of the barcode classification system for fish can facilitate biotaxonomists to distinguish fish species, and it can help the government to verify the authenticity of the ingredients o...
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Article
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic ...
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Characterization, expression patterns and functional analysis of PcMPK12 gene in Phytophthora capsici
Phytophthora capsici is a pathogen of several economically important crops, including pepper (Capsicum annuum). The infection process of P. capsici involves several key developmental steps. This study was conduct...
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Open AccessPA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy
A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...
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Article
Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process. Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline...
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Article
Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa
This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...
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Open AccessRegulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells
Hypoxia is a classic feature of the tumor microenvironment that has profound effects on cancer progression and is tightly associated with poor prognosis. Long noncoding RNAs (lncRNAs), a component of the nonco...
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Paracandidimonas lactea sp. nov., a urea-utilizing bacterium isolated from landfill
A urea-utilizing bacterium, designated Q2-2 T, was isolated from landfill. Cells of strain Q2-2 T were Gram stain-negative, aerobic, short-rod bacteria. Strain Q2-2 T was observed to grow at a temperature range o...
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Wheat genomic study for genetic improvement of traits in China
Bread wheat (Triticum aestivum L.) is a major crop that feeds 40% of the world’s population. Over the past several decades, advances in genomics have led to tremendous achievements in understanding the origin and...
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Validity Analysis of the Morphological Identification of Three Highly Morphologically Similar Species Belonging to the Genus Niviventer (Rodentia: Muridae)
Cryptic species are prevalent among mammals, and identifying morphological methods or measurements that can effectively distinguish cryptic species has high significance in taxonomy. Three of the white-bellied...
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Open AccessThe deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
Dysregulated abundance, location and transcriptional output of Hippo signaling effector TAZ have been increasingly linked to human cancers including head neck squamous cell carcinoma (HNSCC). TAZ is subjected ...
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Open AccessMesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis
There is increasing evidence that mesenchymal stem cells (MSCs) help shape the tumor microenvironment and promote tumor progression, and ion channels might play a critical role in this process. The objective o...
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Open AccessBroader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s
The Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the receptor-binding domain (RBD) of the spike (S) protein. Moreover, host-adapting mutations, such as residues 493, 498, a...
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Open AccessGenome-wide analysis of citrus TCP transcription factors and their responses to abiotic stresses
Citrus is one of the most important fruit crops in the world, and it is worthy to conduct more research on artificially controlling citrus plant growth and development to adapt to different cultivation pattern...
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Open AccessRegulatory network for FOREVER YOUNG FLOWER-like genes in regulating Arabidopsis flower senescence and abscission
FOREVER YOUNG FLOWER (FYF) has been reported to play an important role in regulating flower senescence/abscission. Here, we functionally analyzed five Arabidopsis FYF-like genes, two in the FYF subgroup (FYL1/AGL...
