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135 Result(s)
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**g-Ding Wang
Life Sciences
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Article
Fine map** and genetic analysis identified a C2H2-type zinc finger as a candidate gene for heading date regulation in wheat
A minor-effect QTL, Qhd.2AS, that affects heading date in wheat was mapped to a genomic interval of 1.70-Mb on 2AS, and gene analysis indicated that the C2H2-type zinc finger protein gene TraesCS2A02G181200 is th...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessModerate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice
Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and indu...
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Emerging roles of inositol pyrophosphates in signaling plant phosphorus status and phytohormone signaling
Phosphorus (P) is an indispensable macronutrient serving a variety of functions in plants. Inositol pyrophosphates (PP-InsPs) nutrient messengers play vital roles in the signaling of P status and plant growth ...
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Article
Chemical composition and therapeutic mechanism of Xuanbai Chengqi Decoction in the treatment of COVID-19 by network pharmacology, molecular docking and molecular dynamic analysis
Xuanbai Chengqi Decoction (XBCQD), a classic traditional Chinese medicine, has been widely used to treat COVID-19 in China with remarkable curative effect. However, the chemical composition and potential thera...
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Open AccessHarnessing electromagnetic fields to assist bone tissue engineering
Bone tissue engineering (BTE) emerged as one of the exceptional means for bone defects owing to it providing mechanical supports to guide bone tissue regeneration. Great advances have been made to facilitate t...
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Book
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Article
Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Article
Open AccessStructural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation
Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonis...
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Open AccessIntercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity
STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that activated STING could be transferred...
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Article
Roles of stomata in gramineous crops growth and biomass production
Stomata, microscopic pores surrounded by two guard cells, play essential roles in the most important plant physiological processes: photosynthesis and transpiration. Unlike dicotyledons, grasses, including maj...
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Article
Open AccessMETTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m7G-modified miR-760-dependent manner
7-methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various RNA metabolisms. As the core confirmed transmethylase of m7G modi...
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Article
Open AccessGenome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population
Flowering time and active accumulated temperature (AAT) are two key factors that limit the expanded production especially for soybean across different regions. Wild soybean provides an important germplasm for ...
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Article
Open AccessPhylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family
Alternative splicing (AS) is an important channel for gene expression regulation and protein diversification, in addition to a major reason for the considerable differences in the number of genes and proteins ...
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Article
Open AccessA cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy
Physiological rapid eye movement (REM) sleep termination is vital for initiating non-REM (NREM) sleep or arousal, whereas the suppression of excessive REM sleep is promising in treating narcolepsy. However, th...
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Article
Open AccessRBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis
Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, ...
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Article
Comparative Transcriptome and Hormone Analysis of Mature Leaves and New Shoots in Tea Cuttings (Camellia sinensis) among Three Cultivars with Different Rooting Abilities
Adventitious root (AR) formation is essential for the successful propagation of Camellia sinensis. Endogenous phytohormones play an important role in this process, which is strongly dependent on genotype. However...
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Article
Open AccessBend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation
Understanding the regulatory networks for germ cell fate specification is necessary to develo** strategies for improving the efficiency of germ cell production in vitro. In this study, we developed a coupled sc...
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Article
Open AccessM2-like tumor-associated macrophages transmit exosomal miR-27b-3p and maintain glioblastoma stem-like cell properties
There is growing evidence supporting the implications of exosomes-shuttled microRNAs (miRs) in the phenotypes of glioblastoma stem cells (GSCs), whilst the role of exosomal miR-27b-3p remains to be established...
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Article
EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation
EWI2 is a transmembrane immunoglobulin superfamily (IgSF) protein that physically associates with tetraspanins and integrins. It inhibits cancer cells by influencing the interactions among membrane molecules i...
