720 Result(s)

Article

Hepatic Sirt6 activation abrogates acute liver failure

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...

**que Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner… in Cell Death & Disease (2024)

Article

METTL14 downregulation drives S100A4⁺ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fib...

Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li… in Signal Transduction and Targeted Therapy (2024)

Article

FoxG1 as a Potential Therapeutic Target for Alzheimer’s Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway

An increasing body of research suggests that promoting microglial autophagy hinders the neuroinflammation initiated though the NLRP3 inflammasome activation in Alzheimer’s disease (AD). The function of FoxG1, ...

Qi Yun, Si-Fei Ma, Wei-Ning Zhang, Meng Gu, Jia Wang in Cellular and Molecular Neurobiology (2024)

Article

Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy

Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attentio...

Ya-**n Zhao, Han Wang, Si-Wei Zhang, Wei-**n Zhang… in Cancer Cell International (2024)

Article

Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson’s disease

The pathogenesis of Parkinson’s disease (PD) is strongly associated with neuroinflammation, and type I interferons (IFN-I) play a crucial role in regulating immune and inflammatory responses. However, the spec...

Pusheng Quan, Xueying Li, Yao Si, Linlin Sun… in Cell Communication and Signaling (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and ins...

Wei-Wei Liu, Si-Qing Zheng, Tian Li… in Signal Transduction and Targeted Therapy (2024)

Article

Improved therapeutic consistency and efficacy of CD317⁺ MSCs through stabilizing TSG6 by PTX3

Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma… in Stem Cell Research & Therapy (2024)

Article

Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway

Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI). Pyroptosis acts as a pro-inflammatory form of progr...

Jian Lu, Ya Hou, Si-**u Liu, Bo **, **g Liu, Nan Li… in Cell Communication and Signaling (2024)

Article

Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease

Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceo...

Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun… in Biological Research (2024)

Article

Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG

Bei **g, Zhen-ni Chen, Wai-mei Si, Jia-ji Zhao, Guo-** Zhao… in Molecular Neurobiology (2024)

Article

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...

Chunchun Yuan, **ang-Tian Yu, **g Wang, Bing Shu, **ao-Yun Wang… in Cell Discovery (2024)

Article

The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice

Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related...

Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao… in Cellular & Molecular Biology Letters (2024)

Article

RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway

Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide adenine dinucleotide phosphate (NADPH). The central regions of solid tumors typically ex...

Nan Zhang, Lu Dong, Tingting Ning, Feng Du, Mengran Zhao, Junxuan Xu… in Oncogenesis (2024)

Article

Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer

Despite the successful application of immune checkpoint therapy, no response or recurrence is typical in lung cancer. Cancer stem cells (CSCs) have been identified as a crucial player in immunotherapy-related ...

Lei Ma, Chong Chen, Chunxing Zhao, Tong Li… in Signal Transduction and Targeted Therapy (2024)