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Open AccessImproving the thermostability of Pseudoalteromonas Porphyrae κ-carrageenase by rational design and MD simulation
The industrial applications of the κ-carrageenases have been restricted by their poor thermostability. In this study, based on the folding free energy change (ΔΔG) and the flexibility analysis using molecular ...
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Article
Open AccessCirc_0000376 regulates miR-577/HK2/LDHA signaling pathway to promote the growth, invasion and glycolysis of osteosarcoma
Many studies have confirmed that circular RNAs (circRNAs) mediate the malignant progression of various tumors including osteosarcoma (OS). Our study is to uncover novel molecular mechanisms by which circ_00003...
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Article
Open AccessExperimental sensing quantum atmosphere of a single spin
Understanding symmetry-breaking states of materials is a major challenge in the modern physical sciences. Quantum atmosphere proposed recently sheds light on the hidden world of these symmetry broken patterns....
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Open AccessAutosurv: interpretable deep learning framework for cancer survival analysis incorporating clinical and multi-omics data
Accurate prognosis for cancer patients can provide critical information for optimizing treatment plans and improving life quality. Combining omics data and demographic/clinical information can offer a more com...
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Article
Fermentation of waste water from agar processing with Bacillus subtilis by metabolomic analysis
Fungal infection has become a major threat to crop loss and affects food safety. The waste water from agar processing industries extraction has a number of active substances, which could be further transformed...
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Open AccessHuman apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
Extracellular matrix (ECM) assembly/disassembly is a critical regulator for airway epithelial development and remodeling. Airway organoid is widely used in respiratory research, yet there is limited study to i...
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Open AccessMacro-superlubricity in sputtered MoS2-based films by decreasing edge pinning effect
To date, MoS2 can only be achieved at microscale. Edge pinning effect caused by structure defects is the most obvious barrier to expand the size of structural superlubricity to macroscale. Herein, we plan to pin ...
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Article
Open AccessWrap** gastroduodenal artery stump with the teres hepatis ligament to prevent postpancreatectomy hemorrhage after pancreaticoduodenectomy
Gastroduodenal artery (GDA) stump erosion hemorrhage is a fatal complication after pancreaticoduodenectomy. This study aimed to determine whether GDA stump wrap** with the teres hepatis ligament during pancr...
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Open AccessOrganic photodiodes with bias-switchable photomultiplication and photovoltaic modes
The limited sensitivity of photovoltaic-type photodiodes makes it indispensable to use pre-amplifier circuits for effectively extracting electrical signals, especially when detecting dim light. Additionally, t...
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Open AccessOncological prognosis and morbidity of hepatectomy in elderly patients with hepatocellular carcinoma: a propensity score matching and multicentre study
With increasing life expectancy, the number of elderly patients (≥ 65 years) with hepatocellular carcinoma (HCC) has steadily increased. Hepatectomy remains the first-line treatment for HCC patients. However, ...
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Article
Open AccessResveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal n...
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Article
Open AccessGlobal diversity and biogeography of potential phytopathogenic fungi in a changing world
Phytopathogenic fungi threaten global food security but the ecological drivers of their global diversity and biogeography remain unknown. Here, we construct and analyse a global atlas of potential phytopathoge...
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Article
Open AccessCorrection: Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
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Open AccessThe 100 most cited articles in malignant hyperthermia
Bibliometric analysis is a widely used method to identify and evaluate the trends and characteristics of the scientific publications in a specific research field. A large volume of literature has been publishe...
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Open AccessSCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a metabolic gene CRISPR/Cas9...
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Open AccessDepletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Psoriasis is a common and recurrent inflammatory skin disease characterized by inflammatory cells infiltration of the dermis and excessive proliferation, reduced apoptosis, and abnormal keratosis of the epider...
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Open AccessZ-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1
Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NO...
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Open AccessEffects of C-reactive protein trajectories of critically ill patients with sepsis on in-hospital mortality rate
Sepsis, a life-threatening condition caused by an inflammatory response to systemic infection, results in a significant social burden and healthcare costs. This study aimed to investigate the relationship betw...
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Open AccessThe implications for potential marginal land resources of cassava across worldwide under climate change challenges
The demand for energy plants is foreseen to grow as worldwide energy and climate policies promote the use of bioenergy for climate change mitigation. To avoid competing with food production, it’s critical to a...
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Article
Open AccessLMP2-mRNA lipid nanoparticle sensitizes EBV-related tumors to anti-PD-1 therapy by reversing T cell exhaustion
Targeting EBV-proteins with mRNA vaccines is a promising way to treat EBV-related tumors like nasopharyngeal carcinoma (NPC). We assume that it may sensitize tumors to immune checkpoint inhibitors.
