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Open AccessInhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...
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Article
Linear ubiquitin chain induces apoptosis and inhibits tumor growth
Ubiquitination of proliferating cell nuclear antigen (PCNA) plays an important role in DNA damage response. Ectopic expression of PCNA fused at either terminus with ubiquitin (Ub) lacking two C-terminal glycin...
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Article
Open AccessLipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...
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Article
Open AccessAddition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis
While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) co...
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Article
Open AccessMetformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer ...
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Article
Role of NRP-1 in VEGF-VEGFR2-Independent Tumorigenesis
Recent studies suggest that neuropilin-1 (NRP-1) promotes angiogenesis mainly via VEGF and its receptors. It promotes tumorigenesis via formation of the NRP-1/ VEGF (vascular endothelial growth factor)/VEGFR2 ...
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Article
The role of B7-H1 in gastric carcinoma: clinical significance and related mechanism
The aim of this study was to investigate the role of co-stimulatory molecule B7-H1 in gastric carcinoma, to assess its clinical significance, and to explore related mechanism. Expression of B7-H1 and interfero...
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Article
Low expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in non-Hodgkin lymphoma and a significant correlation with β2-microglobulin
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), a member of the C-type lectin superfamily, has been reported to bind to various pathogens and several tumor cells and t...
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Article
Shorter Dinner-to-Bed Time is Associated with Gastric Cardia Adenocarcinoma Risk Partly in a Reflux-Dependent Manner
Gastric cancer remains the second cause of cancer-related death worldwide. The aim of this study was to investigate the effects of shorter dinner-to-bed time, post-dinner walk, and obesity on gastric cardia ad...
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Article
Open AccessExpression of cancer testis antigens and its correlation with clinicopathological parameters in hepatocellular carcinoma
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Identification of novel serological tumor markers for human prostate cancer using integrative transcriptome and proteome analysis
The aim of this study was to identify novel serological tumor markers for human prostate cancer (PCa). We compared the gene expression profile of PCa tissues to adjacent benign tissues of prostate using gene e...
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Article
Clinical study on the recombinant human endostatin regarding improving the blood perfusion and hypoxia of non-small-cell lung cancer
To observe the dynamic changes of blood perfusion and hypoxic status with CT perfusion imaging and hypoxia imaging in patients of non-small-cell lung cancer (NSCLC) who were treated with recombinant human endo...
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Preliminary clinical study of weekly recombinant human endostatin as a hypoxic tumour cell radiosensitiser combined with radiotherapy in the treatment of NSCLC
To investigate the clinical effects and adverse effects of weekly recombinant human endostatin (RHES) as a hypoxic tumour cell radiosensitiser combined with radiotherapy in the treatment of non-small-cell lung...
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Article
Variation in Cadmium Tolerance and Accumulation and Their Relationship in Wheat Recombinant Inbred Lines at Seedling Stage
In order to identify the variation of cadmium (Cd) tolerance and accumulation in wheat (Triticum aestivum L.), a study was conducted in hydroponic culture with or without Cd using recombinant inbred lines (RILs) ...
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Article
Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
Recent genome-wide association studies have identified seven single nucleotide polymorphisms (SNPs) associated with breast cancer, but mainly in Europeans. In this study, the authors evaluated the effect of th...
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Article
Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer
Runx3 and CHFR genes were defined as tumor suppressor genes in gastric cancer (GC) recently. This paper was to investigate the roles of methylation and expression status of Runx3 and CHFR genes in GC patients....
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Article
Application of proton MR spectroscopy on evaluation of radiotherapy treated intracranial tumors
To evaluate the clinical application of proton magnetic resonance spectroscopy (1HMRS) in patients with radiotherapy treated intracranial tumors.
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Article
Clinical study on concurrent and sequential therapy of intensity modulated radiation therapy (IMRT) combined with NP regimen chemotherapy in the treatment of middle and advanced non-small cell lung cancer
To evaluate the clinical effects of concurrent and sequential therapy for middle and advanced stage non-small cell lung cancer (NSCLC) useing IMRT combined with NP regimen chemotherapy.
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Article
Synuclein Gamma Inhibits the Mitotic Checkpoint Function and Promotes Chromosomal Instability of Breast Cancer Cells
Aberrant expressions of the neuronal protein synuclein gamma (SNCG) in malignant mammary epithelial cells are strongly associated with the progression of breast cancer. SNCG is not expressed in normal breast t...
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Article
The basis of T-cell-mediated immunity to chronic myelogenous leukemia