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Article
Divergent clonal selection dominates medulloblastoma at recurrence
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional ...
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Article
Open AccessStimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury
In this study we examined the relationship between autophagy and apoptosis in diabetic rats after spinal cord injury (SCI), also we determined the role of autophagy in diabetes-aggravated neurological injury in v...
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Article
Open AccessCrude oil as a microbial seed bank with unexpected functional potentials
It was widely believed that oil is a harsh habitat for microbes because of its high toxicity and hydrophobicity. However, accumulating evidence has revealed the presence of live microbes in crude oil. Therefor...
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Article
Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2–macroH2A1 (mH...
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Article
Open AccessThe Relationship between Dietary Protein Consumption and Risk of Fracture: a subgroup and dose-response meta-analysis of prospective cohort studies
It is still debate of the relationship between the dietary protein consumption and risk of fracture. We searched Medline and Embase to assess the effects of dietary protein consumption on risk of fracture. Twe...
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Article
Open AccessDissecting the Mechanism of Martensitic Transformation via Atomic-Scale Observations
Martensitic transformation plays a pivotal role in the microstructural evolution and plasticity of many engineering materials. However, so far the underlying atomic processes that accomplish the displacive tra...
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Article
Open AccessDiverse alkane hydroxylase genes in microorganisms and environments
AlkB and CYP153 are important alkane hydroxylases responsible for aerobic alkane degradation in bioremediation of oil-polluted environments and microbial enhanced oil recovery. Since their distribution in natu...
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Article
Open AccessElectrostatic Induced Stretch Growth of Homogeneous β-Ni(OH)2 on Graphene with Enhanced High-Rate Cycling for Supercapacitors
Supercapacitors, as one of alternative energy devices, have been characterized by the rapid rate of charging and discharging and high power density. But they are now challenged to achieve their potential energ...
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Article
Growth of non-phototrophic microorganisms using solar energy through mineral photocatalysis
Phototrophy and chemotrophy are two dominant modes of microbial metabolism. To date, non-phototrophic microorganisms have been excluded from the solar light-centered phototrophic metabolism. Here we report a p...