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1,545 Result(s)
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Article
Open AccessAuthor Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair
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Open AccessAssociation between age, gender, and oral traumatic ulcerative lesions: a retrospective study
Oral traumatic ulcerative lesions (OTUL) are commonly encountered in clinical practice, yet there is limited research on their clinical characteristics and traumatic etiological factors. This retrospective stu...
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Article
Theoretical analysis of the double-differential cross-sections of neutron, proton, deuteron, \(^3\) He, and \(\alpha\) for the \(\text {p}+^6\) Li reaction
Based on the unified Hauser–Feshbach and exciton model, which can describe the particle emission processes between discrete energy levels with energy, angular momentum, and parity conservations, a statistical ...
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Article
Microstructure evolution and oxidation behavior of silicon-modified aluminide coatings on IN718 superalloy at 1000 °C
Due to the increased service temperature of turbine blades, the high temperature conditions seriously deteriorate the mechanical properties of nickel-based superalloys, thus it is necessary to prepare the anti...
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Article
I-DCGAN and TOPSIS-IFP: A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images
The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ca...
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Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
The tumor microbiome has been characterized in several malignancies; however, no previous studies have investigated its role in intrahepatic cholangiocarcinoma (ICC). Hence, we explored the tumor microbiome an...
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Open AccessOptofluidic crystallithography for directed growth of single-crystalline halide perovskites
Crystallization is a fundamental phenomenon which describes how the atomic building blocks such as atoms and molecules are arranged into ordered or quasi-ordered structure and form solid-state materials. While...
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Article
Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells
Corticosterone (CORT) damages hippocampal neurons as well as induces neuroinflammation. The tricarboxylic acid cycle metabolite itaconate has an anti-inflammatory role. Necroptosis is a form of programmed cell...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...
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Article
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
Ulcerative colitis (UC) is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis, necroptosis of epithelial cells, and mucosal ulcerations. Liver dysfunction and abnormal l...
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Open AccessApplication of tandem mass spectrometry in the screening and diagnosis of mucopolysaccharidoses
Mucopolysaccharidoses (MPSs) are caused by a deficiency in the enzymes needed to degrade glycosaminoglycans (GAGs) in the lysosome. The storage of GAGs leads to the involvement of several systems and even to t...
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Article
Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate
Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP), are known to cause male reproductive damage. Lactiplantibacillus plantarum RS20D has demons...
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Article
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Colorectal cancer (CRC) is a prevalent form of gastrointestinal malignancy with challenges in chemotherapy resistance and side effects. Effective and low toxic drugs for CRC treatment are urgently needed. Ferr...
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Open AccessTIP aquaporins in Cyperus esculentus: genome-wide identification, expression profiles, subcellular localizations, and interaction patterns
Tonoplast intrinsic proteins (TIPs), which typically mediate water transport across vacuolar membranes, play an essential role in plant growth, development, and stress responses. However, their characterizatio...
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Study on the leaching behavior of antimony in stibnite under the action of different oxidants
In order to investigate the release process of antimony from stibnite under the leaching effect of rain and snow in Hunan **kuangshan(XKS) mining area, some important environmental factors are selected: dissol...
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Open AccessIn silico analysis of intestinal microbial instability and symptomatic markers in mice during the acute phase of severe burns
Severe burns may alter the stability of the intestinal flora and affect the patient’s recovery process. Understanding the characteristics of the gut microbiota in the acute phase of burns and their association...
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Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins. However, the anticancer performance of PROTACs is often impaired by their i...
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Open AccessApplication of double plate fixation combined with Masquelet technique for large segmental bone defects of distal tibia: a retrospective study and literature review
There is no effective consensus on the choice of internal fixation method for the Masquelet technique in the treatment of large segmental bone defects of the distal tibia. Thus, the study aimed to investigate ...
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Open AccessKinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis
Kinesin family member 3A (KIF3A) is a microtubule-oriented motor protein that belongs to the kinesin-2 family for regulating intracellular transport and microtubule movement. In this study, we characterized th...
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Heavy metal pollution and ecological risk assessment: A study on Linli County soils based on self-organizing map and positive factorization approaches
This study analyzed the pollution level, distribution, sources, and ecological impact of six heavy metals (As, Cd, Cr, Cu, Zn and Pb) in soil from Linli County, China. The concentration analysis showed that th...