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Article
Phytoestrogens inhibiting androgen receptor signal and prostate cancer cell proliferation
The androgen receptor(AR) signaling activated by dihydrotestosterone(DHT) plays critical roles in prostate cancer development and progression. Phytoestrogens, which are diphenolic compounds with estrogen and a...
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Article
Novel PLGA microspheres for sustained delivery of antisense oligonucleotide
Novel poly(lactide-co-glycolide acid)(PLGA) microspheres were developed for sustained delivery of antisense oligonucleotide(ASO). First, a new cationic agent, polyethylenimine(PEI) conjugated to linoleic acid(...
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Article
Purification and characterization of a novel tetradecapeptide from ginseng polypeptides with enhancing memory activity for mice
Aiming at isolating and investigating the active ingredients of the aqueous extract from Panax ginseng which showed enhancing memory activity, the authors characterized one ingredient. To separate the oligosaccha...
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Article
Determination of amino acids in Panax notoginseng by microwave hydrolysis and derivatization coupled with capillary zone electrophoresis detection
The microwave hydrolysis and derivatization coupled with capillary electrophoresis detection were developed for the separation and determination of the amino acids in Panax notoginseng. The experimental condition...
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Article
Xeno-oestrogens bisphenol a and diethylstilbestrol selectively activating androgen receptor mediated AREs-TATA reporter system
We cloned the three androgen response elements(AREs, including AREI, AREII, and AREIII) with a core transactivation TATA element of the prostate-specific antigen(PSA) promoter into pGL2 basic vector to create an ...
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Article
A QICAR model for metal ion toxicity established via PLS method
The partial least squares(PLS) method was employed to establish a quantitative ion characteristics-activity relationship(QICAR) model for metal ion toxicity(EC50 of 15 metal ions). The ion characteristics include...
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Article
Effects of combinatorial expression of selA, selB and selC genes on the efficiency of selenocysteine incorporation in Escherichia coli
In Escherichia coli, four gene products(selA, selB, selC and selD) and a selenocysteine(Sec) insertion sequence( SECIS) are required for the correct translation of UGA codons encoding Sec. Previous studies have s...
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Article
Low-temperature heat capacities and thermodynamic properties of Mn3(HEDTA)2·10H2O
The low-temperature molar heat capacity of crystalline Mn3(HEDTA)2·10H2O was measured by temperature-modulated differential scanning calorimetry (TMDSC) for the first time. The thermodynamic parameters such as en...
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Article
Heat capacities and thermodynamic properties of MgBTC
A novel two-dimensional metal organic framework MgBTC [MgBTC(OCN)2·2H2O, where BTC = 1,3,5-benzenetricarboxylate] has been synthesized solvothermally and characterized by single crystal XRD, powder XRD, FT-IR spe...
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Article
Chlorofullerenes featuring triple sequentially fused pentagons
The triple sequentially fused pentagons (TSFP) motif is one of the basic subunits that could be used for constructing fullerenes, but it violates the isolated pentagon rule (IPR) and has not been found in carb...