371 Result(s)
within
Neurosciences
**ao-** Sun
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Article
Open AccessBi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease
Parthanatos represents a critical molecular aspect of Parkinson's disease, wherein AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although AIMP2 ought to be a therapeutic target for the...
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Article
Open AccessReorganization of intrinsic functional connectivity in early-stage Parkinson’s disease patients with probable REM sleep behavior disorder
REM sleep behavior disorder (RBD) symptoms in Parkinson’s disease (PD) suggest both a clinically and pathologically malignant subtype. However, whether RBD symptoms are associated with alterations in the organ...
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Article
Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorder (PND) is a common complication of surgery and anesthesia, especially among older patients. Microglial activation plays a crucial role in the occurrence and development of ...
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Article
Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets
The amygdala is an important hub for regulating emotions and is involved in the pathophysiology of many mental diseases, such as depression and anxiety. Meanwhile, the endocannabinoid system plays a crucial ro...
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Article
Open AccessWhite matter changes in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). It is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compa...
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Article
Sex- and age-specific prevalence and risk factors of depressive symptoms in Parkinson’s disease
Although depressive symptoms are common in PD, few studies investigated sex and age differences in depressive symptoms. Our study aimed to explore the sex and age differences in the clinical correlates of depr...
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Article
Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model
Transient ischemic attack (TIA) presents a high risk for subsequent stroke, Alzheimer’s disease (AD), and related dementia (ADRD). However, the neuropathophysiology of TIA has been rarely studied. By evaluatin...
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Article
Astrocyte-Neuronal Communication and Its Role in Stroke
Astrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including...
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Article
The Aging Biomarker Consortium represents a new era for aging research in China
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Article
Integrating network pharmacology and experimental validation to decipher the mechanism of action of **gfang Granule in the treatment of viral myocarditis
This study investigated the mechanisms of **gfang Granule (JFG) in viral myocarditis (VMC) treatment via network pharmacology-based approach combined with molecular docking and validated the results through in v...
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Article
Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function
Amyloid β (Aβ) and tau play pivotal roles in the pathogenesis of Alzheimer’s disease (AD). Previous studies have shown that brain-derived Aβ and tau can be cleared through transport into the periphery, and the...
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Article
Lactate Improves Long-term Cognitive Impairment Induced By Repeated Neonatal Sevoflurane Exposures Through SIRT1-mediated Regulation of Adult Hippocampal Neurogenesis and Synaptic Plasticity in Male Mice
Repeated neonatal exposures to sevoflurane induce long-term cognitive impairment that has been reported to have sex-dependent differences. Exercise promotes learning and memory by releasing lactate from the mu...
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Article
Late-Night Overeating and All-Cause and Cardiovascular Disease Mortality in Adults Aged ≥ 50: A Cohort Study
Late-night overeating (LNOE) is closely associated with many health risk factors, but whether LNOE can increase the risk of death remains unknown. Thus, the prospective cohort study aimed to investigate the re...
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Article
First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial
To explore targeted treatment options in patients with non-small-cell lung cancer (NSCLC) with rare genetic mutations in the context of a patient-centric clinical trial, we initiated, in parallel, a phase 2 ad...
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Article
Open AccessIsoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis
The management of depression continues to be challenging despite the variety of available antidepressants. Herbal medicines are used in many cultures but lack stringent testing to understand their efficacy and...
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Article
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer’s disease (AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to trigger AD-associated d...
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Article
Open AccessLipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury
Neuroinflammation is a vital pathophysiological process during ischemic stroke. Activated astrocytes play a major role in inflammation. Lipocalin-2 (LCN2), secreted by activated astrocytes, promotes neuroinfla...
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Article
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment
Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequ...
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Article
Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the pathogenesis of Alzheimer’s disease (AD). Considerable brain-derived Aβ is cleared via transporting to the periphery....
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Article
Open AccessMolecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway
Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function. The identification of effective anti-inflammat...
