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  1. Article

    Open Access

    Autophagy and multidrug resistance in cancer

    Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative sy...

    Ying-Jie Li, Yu-He Lei, Nan Yao, Chen-Ran Wang, Nan Hu in Chinese Journal of Cancer (2017)

  2. Article

    Open Access

    A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

    Elevated production of reactive oxygen species (ROS) and an altered redox state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective killing of HCC cells by chemotherapeutic ag...

    Nan Yao, Ying-jie Li, Yu-he Lei, Nan Hu in Journal of Experimental & Clinical Cancer … (2016)

  3. Article

    Open Access

    A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma

    The production of autoantibodies against tumour-associated antigens (TAAs) is believed to reflect greater immunologic reactivity in cancer patients and enhanced immune surveillance for cancer cells. Over the p...

    Shang-mian Yie, Shang-rong Ye, **ao-li Ma, Ke **e in British Journal of Cancer (2016)

  4. No Access

    Article

    Emerging role of adipokines in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including lept...

    Hong-Miao Li, Tian-** Zhang, Rui-Xue Leng, **ang-Pei Li in Immunologic Research (2016)

  5. No Access

    Article

    Robo1 promotes angiogenesis in hepatocellular carcinoma through the Rho family of guanosine triphosphatases’ signaling pathway

    Robo1 is a member of the Robo immunoglobulin superfamily of proteins, and it plays an important role in angiogenesis and cancer. In this study, we investigate the role of roundabout 1 (Robo1) in tumor angiogen...

    Jian-Yang Ao, Zong-Tao Chai, Yuan-Yuan Zhang, **ao-Dong Zhu, Ling-Qun Kong in Tumor Biology (2015)

  6. No Access

    Article

    Molecular characteristics of the HSP70 gene and its differential expression in female and male golden apple snails (Pomacea canaliculata) under temperature stimulation

    Heat-shock protein 70 (HSP70) is one of the most important heat-shock proteins that helps organisms to modulate stress response via over-expression. The HSP70 gene from Pomacea canaliculata was cloned using the R...

    Hong-Mei Song, **-Dong Mu, Dang-En Gu, Du Luo, Ye-**n Yang in Cell Stress and Chaperones (2014)

  7. No Access

    Article

    GWAS-linked GAK locus in Parkinson’s disease in Han Chinese and meta-analysis

    Genome-wide association studies of Parkinson’s disease (PD) have recently identified a new susceptibility locus GAK (PARK17) (rs1564282 variant) in subjects of European ancestry. Its role in other races is sti...

    Nan-Nan Li, Xue-Li Chang, Xue-Ye Mao, **-Hong Zhang, Dong-Mei Zhao in Human Genetics (2012)

  8. No Access

    Article

    Interaction of green tea polyphenol epigallocatechin-3-gallate with sunitinib: potential risk of diminished sunitinib bioavailability

    Sunitinib, a novel oral multi-targeted tyrosine kinase inhibitor for patients with metastatic renal cell carcinoma (mRCC) and advanced gastrointestinal stromal tumor, has a good prospect for clinical applicati...

    Jun Ge, Ben-Xu Tan, Ye Chen, Li Yang, **ng-Chen Peng in Journal of Molecular Medicine (2011)

  9. No Access

    Article

    Association analyses identify six new psoriasis susceptibility loci in the Chinese population

    Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.

    Liang-Dan Sun, Hui Cheng, Zai-**ng Wang, An-** Zhang, Pei-Guang Wang in Nature Genetics (2010)

  10. No Access

    Article

    Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

    Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors id...

    Cheng Quan, Yun-Qing Ren, Lei-Hong **ang, Liang-Dan Sun, Ai-E Xu in Nature Genetics (2010)

  11. No Access

    Article

    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

    Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and revea...

    Jian-Wen Han, Hou-Feng Zheng, Yong Cui, Liang-Dan Sun, Dong-Qing Ye in Nature Genetics (2009)

  12. No Access

    Article

    Detection of survivin-expressing circulating cancer cells in the peripheral blood of patients with esophageal squamous cell carcinoma and its clinical significance

    We previously demonstrated that the detection of circulating cancer cells (CCC) expressing survivin mRNA could provide valuable information for predicting recurrence in patients with breast, lung, gastric and ...

    Mei Cao, Shang-Mian Yie, Sheng-Min Wu, Shu Chen in Clinical & Experimental Metastasis (2009)

  13. No Access

    Article

    Poster abstracts

    J. Ferrie, M. Shipley, F. Cappuccio, E. Brunner, M. Miller in Sleep and Biological Rhythms (2007)

  14. Article

    Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury

    Interleukin-1 beta (IL-β) has been implicated as an extracellular signal in the initiation of apoptosis in neurons and oligodendrocytes after spinal cord injury (SCI). To further characterize the apoptotic cas...

    **n-jia Wang, Kang-mei Kong, Wei-li Qi, Wei-lian Ye in Acta Pharmacologica Sinica (2005)

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