82 Result(s)
within
**ang-De Li
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Neurotensin orchestrates valence assignment in the amygdala
The ability to associate temporally segregated information and assign positive or negative valence to environmental cues is paramount for survival. Studies have shown that different projections from the basola...
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Article
Open AccessHigh-fidelity photonic quantum logic gate based on near-optimal Rydberg single-photon source
Compared to other types of qubits, photon is one of a kind due to its unparalleled advantages in long-distance quantum information exchange. Therefore, photon is a natural candidate for building a large-scale,...
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Article
Open AccessModification of BRCA1-associated breast cancer risk by HMMR overexpression
Breast cancer risk for carriers of BRCA1 pathological variants is modified by genetic factors. Genetic variation in HMMR may contribute to this effect. However, the impact of risk modifiers on cancer biology rema...
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Article
Open AccessMidbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone and comorbid conditions. Her...
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Article
Open AccessActive control of micrometer plasmon propagation in suspended graphene
Due to the two-dimensional character of graphene, the plasmons sustained by this material have been invariably studied in supported samples so far. The substrate provides stability for graphene but often cause...
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Article
Behavioural immune landscapes of inflammation
Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing cellular landscapes of healthy and diseased tissues1,2. These approaches, howeve...
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Article
Cell surface and intracellular auxin signalling for H+ fluxes in root growth
Growth regulation tailors development in plants to their environment. A prominent example of this is the response to gravity, in which shoots bend up and roots bend down1. This paradox is based on opposite effect...
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Open AccessDefining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers
Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal t...
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Open AccessPhysiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency
To date, few phenotypes have been described for Arabidopsis 14-3-3 mutants or the phenotypes showing the role of 14-3-3 in plant responding to abiotic stress. Although one member of the 14-3-3 protein family (14-...
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Article
Open AccessIdentification of 22 susceptibility loci associated with testicular germ cell tumors
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with ...
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Article
Open AccessTranscript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma
The spindle and kinetochore-associated protein complex (Ska) is an essential component in chromosome segregation. It comprises three proteins (Ska1, Ska2, and Ska3) with theorized roles in chromosomal instabil...
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Article
Open AccessEfficient 3D printing via photooxidation of ketocoumarin based photopolymerization
Photopolymerization-based three-dimensional (3D) printing can enable customized manufacturing that is difficult to achieve through other traditional means. Nevertheless, it remains challenging to achieve effic...
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Article
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response1....
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Article
Open AccessGenome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration
The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects of its regeneration in nature remain elusive. Here we report chromosome-level genome, ...
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Article
Open AccessUncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
There is the notion that infection with a virulent intestinal pathogen induces generally stronger mucosal adaptive immunity than the exposure to an avirulent strain. Whether the associated mucosal inflammation...
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Article
Open AccessThe Litsea genome and the evolution of the laurel family
The laurel family within the Magnoliids has attracted attentions owing to its scents, variable inflorescences, and controversial phylogenetic position. Here, we present a chromosome-level assembly of the Litsea c...
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Article
The structural basis for cohesin–CTCF-anchored loops
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF1. The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within ...
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Article
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition
KRAS GTPases are activated in one-third of cancers, and KRAS(G12C) is one of the most common activating alterations in lung adenocarcinoma1,2. KRAS(G12C) inhibitors3,4 are in phase-I clinical trials and early dat...
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Article
Open AccessThe water lily genome and the early evolution of flowering plants
Water lilies belong to the angiosperm order Nymphaeales. Amborellales, Nymphaeales and Austrobaileyales together form the so-called ANA-grade of angiosperms, which are extant representatives of lineages that d...
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Article
B cells are associated with survival and immunotherapy response in sarcoma
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation of patients with different subtypes is often atypical, and responses to therap...
