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Article
Open AccessIdentification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice
Circular RNAs (circRNAs) play a role in sepsis-related autophagy. However, the role of circRNAs in autophagy after sepsis-induced cardiomyopathy (SICM) is unknown, so we explored the circRNA expression profile...
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Article
Open AccessHistone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis
E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vas...
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Article
Open AccessIL-33/ST2 axis of human amnion fibroblasts participates in inflammatory reactions at parturition
Inflammation of the fetal membranes is an indispensable event of labor onset at both term and preterm birth. Interleukin-33 (IL-33) is known to participate in inflammation via ST2 (suppression of tumorigenicit...
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Article
Open AccessEfficacy and safety of EGFR‑TKIs plus Shenqi Fuzheng injection for non-small cell lung cancer patients with EGFR-sensitive mutations
The aim of this retrospective study is to evaluate the impact on efficacy and safety between epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) alone and in combination with Shenqi Fuzheng...
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Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Article
Open AccessDriving forces for ultrafast laser-induced sp2 to sp3 structural transformation in graphite
Understanding the microscopic mechanism of photoinduced sp2-to-sp3 structural transformation in graphite is a scientific challenge with great importance. Here, the ultrafast dynamics and characteristics of laser-...
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Article
Open AccessRadiographic and α-fetoprotein response predict pathologic complete response to immunotherapy plus a TKI in hepatocellular carcinoma: a multicenter study
Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...
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Article
Open AccessEarly recombinant human growth hormone treatment improves mental development and alleviates deterioration of motor function in infants and young children with Prader–Willi syndrome
Recombinant human growth hormone (rhGH) therapy has shown to improve height and body composition in children with Prader–Willi syndrome (PWS), the evidence of early rhGH treatment on motor and mental developme...
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Article
Characterization of a novel tetravalent botulism antitoxin based on receptor-binding domain of BoNTs
Botulinum neurotoxin (BoNTs; serotypes A, B, E, and F) cause botulism disease in humans, which could be effectively treated using antitoxins. Herein, we established a novel receptor-binding domain (RBD)-based ...
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Article
Open AccessSystematic pan-cancer analysis identifies SLC31A1 as a biomarker in multiple tumor types
Solute Carrier Family 31 Member 1 (SLC31A1) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that SLC31A1 may play a role in colorectal and lung cancer tumorigenesis. H...
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Article
Open AccessWhole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation
Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident type 2 diabetes (...
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Article
Open AccessAdvancements in nanoparticle-based treatment approaches for skin cancer therapy
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic m...
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Article
Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Article
Open AccessCACA Guidelines for Holistic Integrative Management of Breast Cancer
Breast cancer is now the most common malignant tumor worldwide. About one-fourth of female cancer patients all over the world suffer from breast cancer. And about one in six female cancer deaths worldwide is c...
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Article
Open AccessShort term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...
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Article
Open AccessClinical significance of cyclin-dependent kinase inhibitor 2C expression in cancers: from small cell lung carcinoma to pan-cancers
Cyclin-dependent kinase inhibitor 2C (CDKN2C) was identified to participate in the occurrence and development of multiple cancers; however, its roles in small cell lung carcinoma (SCLC) remain unclear.
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Article
Open AccessPerirenal adipose afferent nerves sustain pathological high blood pressure in rats
Hypertension is a pathological condition of persistent high blood pressure (BP) of which the underlying neural mechanisms remain obscure. Here, we show that the afferent nerves in perirenal adipose tissue (PRA...
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Article
Open AccessAponeurosis discission, a low-detergent method for tissue-engineered acellular ligament scaffolds
Detergent treatment is the most commonly used method for the decellularization of ligaments and tendon grafts. However, it is well recognized that detergent treatment can also adversely affect the extracellula...
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Article
Open AccessComprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencin...
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Article
Open AccessBoron-lead multiple bonds in the PbB2O– and PbB3O2– clusters
Despite its electron deficiency, boron can form multiple bonds with a variety of elements. However, multiple bonds between boron and main-group metal elements are relatively rare. Here we report the observatio...
