1,984 Result(s)
within
Oncology
**-Lin Wang
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Article
Open AccessLoss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan
Elucidation of the basic genetic changes of human hepatocellular carcinoma is important for the understanding and treatment of this cancer. We used microsatellite polymorphism markers to study 30 cases of hepa...
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Open AccessMutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan
To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with B...
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The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene
Overexpression of HER-2/neu (also known as c-erbB-2) proto-oncogene frequently occurs in many different types of human cancers, including ovarian carcinoma, and is known to enhance tumor metastasis and chemoresis...
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Effect of peroxovanadate compound on phenylalanine hydroxylase gene expression
Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can de...
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Article
Selection of Lower Cutoff Point of [13C]Urea Breath Test Is Helpful to Monitor H. pylori Eradication After Proton Pump Inhibitor-Based Triple Therapy
Our objectives were to test the efficacy of [13C] urea breath test (UBT) for H. pylori infection in patients before and after proton pump inhibitor (PPI) based triple therapy, and thus to trace the optimal cutoff...
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Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571
Small cell lung cancer (SCLC) is an aggressive cancer characterized by several autocrine growth mechanisms including stem cell factor and its receptor c-Kit. In order to arrive at potentially new and novel the...
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Article
Enhancement of the photodynamic antitumor effect by streptococcal preparation OK-432 in the mouse carcinoma
Biological response modifier antitumor effects are enhanced by the activation of the host defense mechanisms. We have investigated the antitumor effect of photodynamic therapy (PDT) and/or local administratio...
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Semi-quantitative evaluation of gallium-67 scintigraphy in lupus nephritis
Within nuclear medicine there is a trend towards quantitative analysis. Gallium renal scan has been reported to be useful in monitoring the disease activity of lupus nephritis. However, only visual interpreta...
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Article
The Heterogeneity in Risk Factors of Lung Cancer and the Difference of Histologic Distribution between Genders in Taiwan
Objective: The difference in histologic patterns of lung cancer between men and women in Taiwan may be associated with the heterogeneity in causal factors of lung cancer between the sexes. Methods: Cases consist...
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Philadelphia chromosome-positive acute lymphoblastic leukemia in Taiwan
From January 1986 to December 1998, 26 (23%) of 114 acute lymphoblastic leukemia (ALL) patients older than 15 years were found to have Philadelphia (Ph) chromosome. They accounted for 28% (26 of 94) of the pa...
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Article
External Biliary Drainage plus Bile Acid Feeding Is Not Equal to Internal Drainage in Preserving the Cellular Immunity Following Prolonged Obstructive Jaundice
This study investigates the importance of intestinal bile flow in cellular immunity. Sprague-Dawley rats undergoing bile duct ligation (BDL) and sham ceiliotomy (Sham) for 14 and 21 days were investigated. Exp...
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Article
Modulation of expression of ribosomal protein L7a (rpL7a) by ethanol in human breast cancer cells
Epidemiological studies indicate that there is a positive correlation between alcohol consumption and the risk of breast cancer. Experimental results demonstrate that ethanol is a tumor promoter and chronic et...
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Article
Open AccessDown-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis, tumour-infiltrating cells, and liver damage but accelerates tumour formation in nude mice
Fas-L (CD95L, APO-1L) expresses in a variety of tumours and has been proposed to play a role in tumour formation and metastasis. The contribution of Fas-L to tumour growth, however, is not conclusive especiall...
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Article
Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China
Objective: Ecologic studies of esophageal squamous cell carcinoma (ESCC) have reported an association with consumption of maize contaminated with Fusarium verticillioides, which produce fungal toxins referred to...
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Article
Pretreatment Gastric Histology Is Helpful to Predict the Symptomatic Response After H. pylori Eradication in Patients with Nonulcer Dyspepsia
This study aimed to test whether pretreatment gastric pathology in H. pylori-infected nonulcer dyspepsia (HpNUD) patients is relevant to and predictive of the symptomatic response after H. pylori eradication. Ant...
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Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23
The clinical and biological features of acute myeloid leukemia (AML) with 11q23/MLL translocations are well known, but the characteristics of AML with partial tandem duplication of the MLL gene have not been e...
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Article
Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation
Engagement of the Granulocyte-Colony-Stimulating Factor (G-CSF) receptor activates non-receptor protein tyrosine kinases Lyn and Jak2. We found that Lyn-deficient DT40 cells that express the G-CSF receptor (DT...
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Nuclear Factor-κB and TNF-α Mediate Gastric Ulceration Induced by Phorbol Myristate Acetate
Phorbol esters induce inflammation in rodents by activating protein kinase C. We determined whether nuclear factor-κB (NF-κB) and tumor necrosis factor-α (TNF-α) play role in the formation of gastric ulcer ind...
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Open AccessMutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway
The result of our previous study has shown that the K-ras mutant (pK568MRSV) transfected human adrenocortical cells can significantly increase cortisol production and independently cause cell transformation. The ...
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Inhibition of AKT Oncogenic Pathway in Endometrial Cancer Cells
The PTEN tumor suppressor, which is mutated in 40%–50% of endometrial cancers, is a negative regulator of AKT. In the present study, we examined the activation of AKT in a panel of endometrial cancer cell line...
