245 Result(s)
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Open AccessLattice-mismatch-free construction of III-V/chalcogenide core-shell heterostructure nanowires
Growing high-quality core-shell heterostructure nanowires is still challenging due to the lattice mismatch issue at the radial interface. Herein, a versatile strategy is exploited for the lattice-mismatch-free...
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Open AccessHumoral and cellular immunity against different SARS-CoV-2 variants in patients with chronic kidney disease
Chronic kidney disease (CKD) patients are at higher risk of severe COVID-19. Humoral and cellular immunity from prior infection or vaccination are important for protection, but the neutralizing antibody (nAb) ...
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Open AccessNULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing
The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we addres...
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Minutes-duration optical flares with supernova luminosities
In recent years, certain luminous extragalactic optical transients have been observed to last only a few days1. Their short observed duration implies a different powering mechanism from the most common luminous e...
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Open AccessFAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
Cold stimulation dynamically remodels mitochondria in brown adipose tissue (BAT) to facilitate non-shivering thermogenesis in mammals, but what regulates mitochondrial plasticity is poorly understood. Comparin...
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Open AccessVoltage control of magnetism in Fe3-xGeTe2/In2Se3 van der Waals ferromagnetic/ferroelectric heterostructures
We investigate the voltage control of magnetism in a van der Waals (vdW) heterostructure device consisting of two distinct vdW materials, the ferromagnetic Fe3-xGeTe2 and the ferroelectric In2Se3. It is observed ...
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Open AccessMechanical stimuli activate gene expression via a cell envelope stress sensing pathway
Mechanosensitive mechanisms are often used to sense damage to tissue structure, stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well recognized in eukaryotic systems, i...
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Open AccessTransitions of dialysis status and outcomes after the unplanned first dialysis: a nationwide population-based cohort study
In Taiwan, most first-time dialysis was started without the creation of an arteriovenous shunt. Here, we aimed to elucidate the transitions of dialysis status in the unplanned first dialysis patients and deter...
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Open AccessMolecular system for an exponentially fast growing programmable synthetic polymer
In this paper, we demonstrate a molecular system for the first active self-assembly linear DNA polymer that exhibits programmable molecular exponential growth in real time, also the first to implement “internal” ...
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Open AccessCFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis
Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to ...
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Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Open AccessCorrelated insulator collapse due to quantum avalanche via in-gap ladder states
The significant discrepancy observed between the predicted and experimental switching fields in correlated insulators under a DC electric field far-from-equilibrium necessitates a reevaluation of current micro...
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Open AccessAlanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss
SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient in either ATPase have been shown to depend on th...
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Open AccessAchromatic and chromatic contrast discrimination in patients with type 2 diabetes
Effects of type 2 diabetes on achromatic and chromatic contrast sensitivity (CS) are still controversial. In this study, we aimed to investigate CS in patients without diabetic retinopathy (no-DR) and in those...
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Open AccessStructural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of...
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Open AccessImproved photovoltaic performance and robustness of all-polymer solar cells enabled by a polyfullerene guest acceptor
Fullerene acceptors typically possess excellent electron-transporting properties and can work as guest components in ternary organic solar cells to enhance the charge extraction and efficiencies. However, conv...
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Open AccessMethylammonium halide salt interfacial modification of perovskite quantum dots/triple-cation perovskites enable efficient solar cells
Perovskite solar cells (PeSCs) have been introduced as a new photovoltaic device due to their excellent power conversion efficiency (PCE) and low cost. However, due to the limitations of the perovskite film it...
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Open AccessA ring-like accretion structure in M87 connecting its black hole and jet
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure...
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Mechanistic formulation of inorganic membranes at the air–liquid interface
Freestanding functional inorganic membranes, beyond the limits of their organic and polymeric counterparts1, may unlock the potentials of advanced separation2, catalysis3, sensors4,5, memories6, optical filtering
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Open AccessAnalytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson’s disease in Japan
Continuous, objective monitoring of motor signs and symptoms may help improve tracking of disease progression and treatment response in Parkinson’s disease (PD). This study assessed the analytical and clinical...
