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Open AccessA review on recent advances on nobiletin in central and peripheral nervous system diseases
In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fa...
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ASO Video Abstract: Neoadjuvant Chemo-Immunotherapy Increases Tumor Immune Lymphocytes Infiltration in Resectable NSCLC
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Open AccessLymphangiogenesis in gastric cancer: function and mechanism
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis. There is increasing evidence that the lympha...
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Article
Open AccessClinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study
Interstitial lung disease (ILD) is a severe complication of connective tissue disease (CTD) that can significantly impact patients' prognosis and quality of life. However, the current diagnostic arena lacks re...
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Open AccessDevelopment and validation of a competitive risk model in patients with rectal cancer: based on SEER database
Rectal cancer is one of the most common malignancies. To predict the specific mortality risk of rectal cancer patients, we constructed a predictive nomogram based on a competing risk model.
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Open AccessPrediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
Melanoma is the deadliest form of skin tumor, and G protein-coupled receptors (GPCRs) play crucial roles in its carcinogenesis. Furthermore, the tumor microenvironment (TME) affects the overall survival (OS) a...
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Open AccessA hypoxia- and lactate metabolism-related gene signature to predict prognosis of sepsis: discovery and validation in independent cohorts
High throughput gene expression profiling is a valuable tool in providing insight into the molecular mechanism of human diseases. Hypoxia- and lactate metabolism-related genes (HLMRGs) are fundamentally dysreg...
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Open AccessA prediction model for permanent pacemaker implantation after transcatheter aortic valve replacement
This study aims to develop a post-procedural risk prediction model for permanent pacemaker implantation (PPMI) in patients treated with transcatheter aortic valve replacement (TAVR).
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Correction: Dysregulated microRNAs participate in the crosstalk between colorectal cancer and atrial fibrillation
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Role of cuproptosis in understanding diseases
Cell death is involved in a wide range of physiological and pathological processes. Recently, the term “cuproptosis” was coined to describe a novel type of cell death. This type of cell death, characterized by...
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Article
Open AccessThe value of serum IL-4 to predict the survival of MDS patients
Immune indicators are routinely used for the detection of myelodysplastic syndrome (MDS), but these are not utilized as a reference indicator to assess prognosis in MDS-related prognostic evaluation systems, s...
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Open AccessA c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans
The postoperative survival of oral squamous cell carcinoma (SCC) relies on precise detection and complete resection of original tumors. The mucosal extension of the tumor is evaluated visually during surgery, ...
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Open AccessThe ratio of monocytes to lymphocytes multiplying platelet predicts incidence of pulmonary infection-related acute kidney injury
Inflammation is a crucial factor in the pathogenesis and development of acute kidney injury (AKI). Macrophages, as an important innate immune cell, regulate immune response and play a pathophysiological role i...
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Open AccessEarly predicting 30-day mortality in sepsis in MIMIC-III by an artificial neural networks model
Early identifying sepsis patients who had higher risk of poor prognosis was extremely important. The aim of this study was to develop an artificial neural networks (ANN) model for early predicting clinical out...
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ASO Author Reflections: Are Older Patients with Proximal Femoral Bone Metastases Fit for Endoprosthetic Replacement?
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Open AccessGlobal trends and frontiers in research on coronary microvascular dysfunction: a bibliometric analysis from 2002 to 2022
Coronary microvascular dysfunction (CMD) is a leading cause of ischemic heart disease. Over the past few decades, considerable progress has been made with respect to research on CMD. The present study summariz...
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Open AccessLPCAT1 acts as an independent prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is overexpressed in multiple human tumors. However, the role of LPCAT1 in hepatocellular carcinoma (HCC) has not been understood. We aim to explore the relati...
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Open AccessExosome-mediated effects and applications in inflammatory diseases of the digestive system
Exosomes are membranous vesicles containing RNA and proteins that are specifically secreted in vivo. Exosomes have many functions, such as material transport and signal transduction between cells. Many studies...
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Open AccessFactors associated with left ventricular diastolic dysfunction in patients with septic shock
To investigate risk factors associated with left ventricular diastolic dysfunction (LVDD) of patients with septic shock.
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Open AccessWhich patients are prone to suffer liver metastasis? A review of risk factors of metachronous liver metastasis of colorectal cancer
In recent years, with the increasing incidence of colorectal cancer (CRC) and its high fatality rate, CRC has seized the attention of the world. And liver metastasis, as the main cause of death of CRC, has bec...