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  1. No Access

    Article

    Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells

    Previous study has demonstrated that mitochondrial-dependent apoptotic pathway is involved in the nephroprotective effect of puerarin (PU) against lead-induced cytotoxicity in primary cultures of rat proximal ...

    Zhong-Kun Wang, Xue-Lei Zhou, **ang-Bin Song… in Biological Trace Element Research (2016)

  2. No Access

    Article

    Assessment of biostimulation and bioaugmentation for removing chlorinated volatile organic compounds from groundwater at a former manufacture plant

    Site in a former chemical manufacture plant in China was found contaminated with high level of chlorinated volatile organic compounds (CVOCs). The major contaminants chloroform (CF), 1,2-dichloroethane (1,2-DC...

    Shu Zhang, Zhen Hou, **ao-ming Du, Dong-ming Li, **ao-xia Lu in Biodegradation (2016)

  3. No Access

    Article

    Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives

    Artemisinin-based combination therapy (ACT) forms the frontline treatment of malaria. Artemisinin, an endoperoxide sesquiterpenoid lactone biosynthesized by Artemisia annua, is the effective medicine that kills m...

    De-Yu **e, Dong-Ming Ma, Rika Judd, Ashley Loray Jones in Phytochemistry Reviews (2016)

  4. No Access

    Article

    Modulatory role of L-carnitine against microcystin-LR-induced immunotoxicity and oxidative stress in common carp

    Microcystin-LR (MCLR), one of the most popular microcystins (MCs) found in many field water bodies around the world, poses great health risks to animals and humans. In the present study, healthy common carp (i...

    **u-Mei Chen, Gui-Liang Guo, Li Sun, Qiu-Shi Yang… in Fish Physiology and Biochemistry (2017)

  5. No Access

    Article

    Characterization of the complete chloroplast genome of Dalbergia hainanensis (Leguminosae), a vulnerably endangered legume endemic to China

    Dalbergia hainanensis is a vulnerably endangered tree species with high economic and ornamental value. The complete chloroplast (cp) genome of D. hainanensis was determined to provide the underlying information f...

    Chuan-Yuan Deng, Gui-Liang **n, Jian-Qiang Zhang… in Conservation Genetics Resources (2019)

  6. No Access

    Article

    Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus

    The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. A basal diet was ...

    Mu-Yang Li, **n-Ming Zhu, **ao-Tian Niu, **u-Mei Chen… in Molecular Biology Reports (2019)

  7. Article

    Open Access

    The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling

    Paired-box 6 (PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it is also expressed in several types of tum...

    Dong-ming Wu, Ting Zhang, Ya-bin Liu, Shi-hua Deng, Rong Han… in Cell Death & Disease (2019)

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  8. No Access

    Article

    Astaxanthin enhances hematology, antioxidant and immunological parameters, immune-related gene expression, and disease resistance against in Channa argus

    The present study was aimed to add 0, 50, or 100 mg/kg of astaxanthin (AST) to the basal diet of Channa argus and determine the effects on hematology, antioxidant and immunological parameters, immune-related gene...

    Mu-Yang Li, **n-Yu Liu, Chang-Ge **a, Gui-Qin Wang… in Aquaculture International (2019)

  9. No Access

    Article

    Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1

    Intestinal epithelia self-renew constantly and generate differentiated cells such as secretary goblet cells. The intestine goblet cells secrete gel-forming mucins that form mucus to create a barrier of defense...

    Yi-ming Xu, Qiang Gao, **-zhao Zhang, Yun-tao Lu… in Cell Death & Differentiation (2020)

  10. Article

    Open Access

    Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

    Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a ...

    Yu-Pei Chen, Jian-Hua Yin, Wen-Fei Li, Han-Jie Li, Dong-** Chen… in Cell Research (2020)

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  11. No Access

    Article

    Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors

    PD-1/PD-L1 axis represents an important target for renormalizing and resetting anti-tumor immunity in cancer patients. Currently, anti-PD-1/PD-L1 therapy has been applied in a broad spectrum of tumors and has ...

    Yuan Wei, **ao **ao, **ang-Ming Lao, Limin Zheng… in Cellular and Molecular Life Sciences (2021)

  12. No Access

    Article

    SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin

    Mitochondrial unfolded protein response plays an important role in the occurrence and development of breast cancer. However, the role of mitochondrial unfolded protein response (UPRmt) in the sensitivity of breas...

    Hao Chen, Dong-Ming Zhang, Zhi-** Zhang, Ming-Zhang Li, Hai-Feng Wu in Genes & Genomics (2021)

  13. Article

    Open Access

    CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition

    Circular RNAs (circRNAs) belong to an abundant category of non-coding RNAs that are stable and specific, and thus have great potential in cancer treatment. However, little is known about the role of circRNAs d...

    Ting Zhang, Dong-Ming Wu, Peng-Wei Luo, Teng Liu, Rong Han… in Cell Death & Disease (2022)

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  14. Article

    Open Access

    Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses

    Acute lung injury (ALI) has received considerable attention in the field of intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in citrus fruits, is a natural bioactive ...

    ** Li, Shi-hua Deng, **g Li, Li Li, Feng Zhang… in Cellular & Molecular Biology Letters (2022)

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  15. No Access

    Article

    Effects of different stocking densities on the growth performance and antioxidant capacity of Chinese mitten crab (Eriocheir sinensis) in rice crab culture system

    This study assessed the effects of stocking density (D02, 0.2 individuals/m2; D03. 0.3 individuals/m2; D04, 0.4 individuals/m2; D05, 0.5 individuals/m2; D06, 0.6 individuals/m2) on Chinese mitten crab (Eriocheir ...

    **n Wang, Qi Yao, **n-yu Lei, Dong-ming Zhang, Sen Wang… in Aquaculture International (2022)

  16. Article

    Open Access

    Targeting NAD+: is it a common strategy to delay heart aging?

    Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numero...

    Yang Yuan, Bing Liang, **n-Lin Liu, Wen-**g Liu, Bing-Huan Huang… in Cell Death Discovery (2022)

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  17. No Access

    Article

    Isolation and characterization of AaZFP1, a C2H2 zinc finger protein that regulates the AaIPPI1 gene involved in artemisinin biosynthesis in Artemisia annua

    AaZFP1, a C2H2-type transcription factor, was found to bind the AGT-N1-10-AGT box of AaIPPI1pro and activate the expression of AaIPPI1 involved in artemisinin biosynthesis.

    Yin-ai Deng, Li Li, Qian Peng, Ling-fang Feng, **-fen Yang, Ruo-ting Zhan… in Planta (2022)

  18. Article

    Open Access

    Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3/GSDMD pathway in pulmonary bronchial epithelia

    Aspergillus fumigatus infection is difficult to diagnose clinically and can develop into invasive pulmonary aspergillosis, which has a high fatality rate. The incidence of Aspergillus fumigatus infection has incr...

    Dong-Ming Wu, Miao He, Yang-Yang Zhao, Shi-Hua Deng… in Cell Communication and Signaling (2022)

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  19. No Access

    Article

    Dietary supplementation of two indigenous Bacillus spp on the intestinal morphology, intestinal immune barrier and intestinal microbial diversity of Rhynchocypris lagowskii

    This study evaluated the effects of dietary administration of two indigenous Bacillus (A: basal control diet; B: 0.15 g/kg of Bacillus subtilis; C: 0.1 g/kg of Bacillus subtilis and 0.05 g/kg of Bacillus lichenif...

    **n-yu Lei, Dong-ming Zhang, Qiu-ju Wang, Gui-qin Wang… in Fish Physiology and Biochemistry (2022)

  20. No Access

    Article

    Osmoregulation, physiological metabolism, and oxidative stress responses to water salinity in adult males of Chinese mitten crabs (Eriocheir sinensis)

    This study investigated the effects of water salinity (0‰, 15‰, and 30‰) on osmoregulation, physiological metabolism, antioxidant capacity, inflammatory response, and anti-stress factors of Chinese mitten crabs (

    **n Wang, Zhi-xin Guo, **n-yu Lei, Sen Wang, Ji-wu Wan… in Aquaculture International (2023)

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