39 Result(s)
within
Immunology
Medical Microbiology
Qi** Li
Chapter
Biomedicine
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Chapter
Human Microbiota and Its Function
The human body is home to complex communities of microorganisms. Their total number is estimated to be 1014; 10 times the number of human cells per individual [1]. These microbial communities are found on our ski...
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Chapter
Future Development of Infectious Microecology
More and more studies indicate interactions between infectious diseases and microbiota. Advances in molecular techniques have led to a greater appreciation of the diversity of human microbiota, the extent of i...
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Chapter
Humanized Mouse Versus Non-human Primate Models of HIV-1 Infection
Animal models are critical for biomedical research including human immunodeficiency virus type one (HIV-1). Asian non-human primate (NHP) macaques and humanized mice (hu-mice) are the two best available models...
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NK Cell Development in Human Immune System (HIS) Mice and Their Role in HIV Pathogenesis
Studies on mouse natural killer (NK) cells reveal their major role in host innate immunity against viral pathogens and tumor cells. In recent years, there has been a growing interest to develop therapeutics an...
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Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice
The thymus is an organ that generates and educates T cells, supplying T subsets that ensure adaptive immunity and self-tolerance. Intrathymic positive selection of T cells with further post-thymic maturation a...
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Chapter
Infectious Microecology
Microecology, with information increasing rapidly, has been a new develo** subject. In recent years, the discipline of microecology has become a significant subject studied by international scientists. Some ...
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Facets of Small RNA-Mediated Regulation in Legionella pneumophila
Legionella pneumophila is a water-borne pathogen that causes a severe lung infection in humans. It is able to replicate inside amoeba in the water environment, and inside lung macrophages in...
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Infectious Microecology in Liver Disease
More than 100 years ago, Pavlov discovered that the liver can remove enteric toxins. Now we think that, under normal circumstances, the liver can also remove bacteria, fungi, and their metabolites such as toxi...
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Infectious Microecology in Urinary Tract and Reproductive System
Urinary tract infection (UTI) is an infection involving the kidneys, ureters, bladder, or urethra. These are the structures that urine passes through before being eliminated from the body. Symptoms include fre...
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Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. H...
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LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide
Cationic host defence peptides (CHDP) are conserved peptide components of the innate immune system. These peptides, also known as antimicrobial peptides, were originally discovered and described on the basis o...
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Studying Salmonellae and Yersiniae Host–Pathogen Interactions Using Integrated ‘Omics and Modeling
Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both...
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Chromatin Remodeling and Androgen Receptor-Mediated Transcription
It has become apparent that the expression of human genes in chromatin is regulated by post-translational structural changes in histones, which form the major protein component of nucleosomes in chromatin. The...
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The Development, Activation, Function and Mechanisms of Immunosuppressive Double Negative (DN) T Cells
Double negative (DN) T cells are a subset of T cells, present in the peripheral lymphatic organs and blood in very low numbers (1–2% of lymphocytes) in mice and humans. DN T cells have been shown to inhibit tr...
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Images of Cleavage: Tumor Proteases in Action
The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrices during tumor invasion and metastasis. Furthermore, proteases from tumor-associated cells (e.g...
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Chapter
Anti-Adhesion and Diagnostic Strategies for Oro-Intestinal Bacterial Pathogens
Bacteria, viruses and eukaryotic cells bind to carbohydrate and protein receptors via cell adhesion molecules (Sharon and Lis, 1993). Adhesion is an essential step in microbial colonization and the development...
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Chapter
Phenotypic and Genotypic Analysis of Chinese Borrelia Burgdorferi from Various Sources
Lyme borreliosis, a multisystem disorder caused by the spirochete B. burgdorfer, is a worldwide tick-borne disease. Many clinical cases of B. burgdorferi infections have been described in humans and animals. B...
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Chapter
The Beginning and the End of the Development of TCRγδ Cells in the Thymus
The thymus is primarily a site for the expansion, differentiation and selection of develo** cells of the TCR-αβ lineage. However, TCR-γδ cells also develop in the thymus, and are found primarily within the CD- ...
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Chapter and Conference Paper
T-Cell Recognition of HLA Class I Molecules
The purpose of the Class I T-Cell Clone component of the Tenth Workshop (10WS) was to determine the extent to which HLA class I molecules express polymorphisms recognizable by alloreactive or antigen-specific ...
