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Metabolic Diseases
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Open AccessCongenital anomalies in pregnancies with overt and pregestational type 2 diabetes: a gray portrayal from a cohort in Brazil
To describe the frequency and types of congenital anomalies and associated risk factors in Brazilian women with type 2 diabetes.
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Open AccessThe relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients
Stroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in gastrointestinal cancers, including colorectal cancer (CRC), defined as dire...
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Open AccessSelf-care practice and associated factors among patients with diabetes on follow-up at Yirgalem General Hospital, Sidama, Ethiopia: a cross-sectional study
Self-care practice is an integral and efficient part of comprehensive diabetes management, which could be influenced by various socio-demographic, clinical, and lifestyle factors.
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Open AccessMolecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Alterations in circadian rhythms increase the likelihood of develo** type 2 diabetes and CVD. Circadian rhythms are controlled by several core clock genes, which are expressed in nearly every cell, including...
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Open AccessRelationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D in patients with type 2 diabetes mellitus
We aimed to analyze the relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D (25(OH)D) in patients with type 2 diabetes mellitus.
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Open AccessDried fruit intake and lower risk of type 2 diabetes: a two-sample mendelian randomization study
Previous studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine the potential causal effect of dried fruit intake on type 2 diabetes by ...
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The effect of coffee consumption on three main bone disorders: a Mendelian randomization trial
Despite a large number of observational studies examining the effect of coffee consumption(CC) on bone disorders(BDs), particularly, osteoarthritis(OA), osteoportic fracture(OF), and rheumatoid arthritis(RA), ...
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Open AccessObesity as a disease: a pressing need for alignment
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Open AccessUrine biomarkers in type 2 diabetes mellitus with or without microvascular complications
To investigate the distribution of nine (9) urine biomarkers in people living with type 2 diabetes mellitus (T2DM), with or without microvascular complications.
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The obesity-related mutation gene on nonalcoholic fatty liver disease
The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive accumulation of liver fat and a risk of develo** hepatocellular ...
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Open AccessEfficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
The aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes insufficiently controlled with diet and exerc...
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Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism
Astrocytes are the most numerous type of glial cells found in the nervous system. They regulate energy homeostasis in collaboration with the neuronal circuits involved in energy balance. These glial cells are ...
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Open AccessDiacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1/ PON 1
This study aimed to explore the impact of Diacerein (DIC) on endocrine and cardio-metabolic changes in polycystic ovarian syndrome (PCOS) mouse model.
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Open AccessA mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults
To identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
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Open AccessEfficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
The aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes inadequately controlled with metformin treatment.
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Open AccessDevelo** and validating a Modified Cachexia Index to predict the outcomes for colorectal cancer after radical surgery
It was reported that the cachexia index (CXI: \(\frac{{\rm{ALB}}* {\rm{SMI}}}{{\rm{NLR}}}\) ...
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Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat
The current obesity crisis has resulted in many people with excess adipose tissue suffering from chronic inflammation. This inflammation is largely due to the release of cytokines and chemokines from visceral ...
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Open AccessDrug utilization pattern of romosozumab and other osteoporosis treatments in Japan, 2019–2021
Describe real-world treatment of osteoporosis and romosozumab treatment patterns in Japan.
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Open AccessUnveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 map**
This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 map**.
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End of an era: the passing of pioneers of cloning
