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Article
Wenying **ng
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Open AccessCerebrospinal fluid α-synuclein adds the risk of cognitive decline and is associated with tau pathology among non-demented older adults
The role of α-synuclein in dementia has been recognized, yet its exact influence on cognitive decline in non-demented older adults is still not fully understood.
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Open AccessGALAD score as a prognostic model for recurrence of hepatocellular carcinoma after local ablation
Currently, the high recurrence rate still forms severe challenges in hepatocellular carcinoma (HCC) treatment. The GALAD score, including age, gender, alpha-fetoprotein (AFP), lens culinaris agglutinin-reactiv...
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PP-Loss: An imbalanced regression loss based on plotting position for improved precipitation nowcasting
Precipitation nowcasting refers to the accurate and timely forecasting of rainfall in a certain area for the near future, which plays a key role in severe convective weather warnings, water resources, and floo...
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Open AccessRelationship between socioeconomic status and hypertension incidence among adults in southwest China: a population-based cohort study
To investigate the correlation between socioeconomic status (SES) and the incidence of hypertension among adults aged 18 or above in southwest China.
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Open AccessThe impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites
To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecut...
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Open AccessStatus of self-medication and the relevant factors regarding drug efficacy and safety as important considerations among adolescents aged 12–18 in China: a cross-sectional study
The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12–18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety...
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Identifying vital spreaders in complex networks based on the interpretative structure model and improved Kshell
The identification of vital spreaders in complex networks has been one of the most interesting topics in network science. Several methods were proposed to deal with this challenge, but there still exist defici...
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Heat shock protein HvHSP16.9 from wild barley enhances tolerance to salt stress
Heat shock proteins (HSPs) are known to play a crucial role in the response of plants to environmental stress, particularly heat stress. Nevertheless, the function of HSPs in salt stress tolerance in plants, espe...
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Open AccessRBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5
Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms of their involvement in transcriptional proces...
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Metagenomic Next-Generation Sequencing Contributes to the Early Diagnosis of Mixed Infections in Central Nervous System
Central nervous system (CNS) infections represent a challenge due to the complexities associated with their diagnosis and treatment, resulting in a high incidence rate and mortality. Here, we presented a case ...
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Open AccessExpression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis
Mechanosensitive ion channel PIEZOs have been widely reported to involve inflammation and pain. This study aimed to clarify expression patterns of PIEZOs and their potential relations to irreversible pulpitis.
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Characterization and functional analysis of microbial communities in Bletilla striata
The connection between the traditional Chinese medicinal herb Bletilla striata and microorganisms is still not well understood. Our study aimed to uncover the structure and diversity of the fungal and bacterial c...
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Open AccessNuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compa...
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Open AccessDevelopment and validation of an ultrasound-based deep learning radiomics nomogram for predicting the malignant risk of ovarian tumours
The timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on u...
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Open AccessNurses’ perspectives on professional self-concept and its influencing factors: A qualitative study
Nurses with a strong professional self-concept tend to exhibit a positive mindset and strong work engagement, delivering high-quality patient care. Although numerous quantitative studies have examined the fact...
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Open AccessTheoretical analysis of hydrogen solubility in direct coal liquefaction solvents
The cyclic hydrogenation technology in a direct coal liquefaction process relies on the dissolved hydrogen of the solvent or oil participating in the hydrogenation reaction. Thus, a theoretical basis for proce...
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Interaction mechanisms of ACE inhibitory peptides: molecular docking and molecular dynamics simulation studies on five wheat gluten derived peptides
The angiotensin I-converting enzyme (ACE) inhibitory activity of five wheat gluten-derived peptides Ala-Pro-Ser-Tyr (APSY), Leu-Val-Ser (LVS), Leu-Tyr (LY), Arg-Gly-Gly-Tyr (RGGY), and Tyr-Gln (YQ) was investi...
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Open AccessOrigin and dispersal history of Hepatitis B virus in Eastern Eurasia
Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We prese...
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Open AccessEfficacy and safety of oral ibrexafungerp in Chinese patients with vulvovaginal candidiasis: a phase III, randomized, double-blind study
To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).
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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes
Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our previous study showed that increasing the expression of Siglec...
