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Article
Observation of Nasal Morphology in Unilateral Microform Cleft Lip Repaired by a Hidden Skin Incision
Microform cleft lip is the mildest type of cleft lip without obvious defects of the upper lip. The nose deformities of microform cleft lip include flattened nostril rim, alar base asymmetry, and septal deviati...
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Article
Enhanced electrode reaction for La0.8Sr0.2FeO3-δ-Sm0.2Ce0.8O1.9 composite cathode by barium carbonate nanoparticles as a synergistic catalyst
BaCO3 nanoparticles are demonstrated as outstanding catalysts for high-temperature oxygen reduction reaction on the La0.8Sr0.2FeO3-δ (LSF)-Sm0.2Ce0.8O2−δ (SDC) cathode for solid oxide fuel cells (SOFCs). X-ray di...
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Article
Multiphase evolution of a Li-pegmatite field from the Tashisayi area, Altyn Tagh, NW China: insights from a petrological, geochemical, and geochronological study
The Tashisayi Li deposit was newly discovered in the eastern part of the Tashisayi batholith, located in the Altyn Tagh region of Northwest China. A Li-rich composite pegmatite-aplite dyke (γ02) displays super...
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Article
The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown...
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Article
Improvement of thermostability by increasing rigidity in the finger regions and flexibility in the catalytic pocket area of Pseudoalteromonas porphyrae κ-carrageenase
Poor thermostability reduces the industrial application value of κ-carrageenase. In this study, the PoPMuSiC algorithm combined with site-directed mutagenesis was applied to improve the thermostability of the ...
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Article
Diagnostic performance of radiomics for predicting osteoporosis in adults: a systematic review and meta-analysis
This study aimed to assess the diagnostic accuracy of radiomics for predicting osteoporosis and the quality of radiomic studies. The study protocol was prospectively registered on PROSPERO (CRD42023425058). We...
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Article
Microscopic internal spermatic-inferior epigastric vein anastomosis for treating left varicocele
To evaluate the clinical efficacy of microscopic internal spermatic-inferior epigastric vein anastomosis in the treatment of left varicocele and compare it with microscopic spermatic vein ligation for the same...
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Article
Open AccessUltrasonography screening of hepatic cystic echinococcosis in sheep flocks used for evaluating control progress in a remote mountain area of He**g County, **njiang
Although ultrasonography (US) has been widely used in the diagnosis of human diseases to monitor the progress of cystic echinococcosis (CE) control, the screening method for hepatic CE in sheep flocks requires...
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Article
Open AccessE3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...
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Article
Open AccessComparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds
Hu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its “year-round estrus and multiple births” and is an ideal model for studying the high fecundity mechanisms of livestock. Through ana...
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Article
Open AccessInterventional therapy combined with tyrosine kinase inhibitors with or without immune checkpoint inhibitors as initial treatment for hepatocellular carcinoma with portal vein tumor thrombosis: a systematic review and meta-analysis
Interventional therapy, in conjunction with tyrosine kinase inhibitors (TKIs), has shown promising outcomes for treating hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). With the advent...
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Article
Adaptive stochastic resonance under Poisson white noise background and its application for bolt looseness detection
Bolts are utilised extensively in machinery and often bear large loads. Reliable connection of bolts is related to the effective functioning of machinery. Therefore, it is of utmost importance to detect bolt l...
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Article
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomplete efficacy. Therefore, a clinically consistent animal model of BAVM is urgently needed...
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Article
Open AccessUnconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been asso...
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Article
Crack Coalescence Mechanism and Crack Type Determination Model Based on the Analysis of Specimen Apparent Strain Field Data
Clarifying the crack coalescence mechanism and defining crack types within flawed rock formations offer significant advantages for understanding the failure process of geomaterials in practical geotechnical en...
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Article
Clinical characteristics and predictive factors of delayed diagnosis in patients with sellar germ cell tumors
To investigate the clinical characteristics and predictive factors associated with delayed diagnosis in patients with sellar germ cell tumors (GCTs), aiming for early diagnosis.
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Article
USF2 activates RhoB/ROCK pathway by transcriptional inhibition of miR-206 to promote pyroptosis in septic cardiomyocytes
Septic cardiomyopathy (SCM) is one of the most serious complications of sepsis. The present study investigated the role and mechanism of upstream stimulatory factor 2 (USF2) in SCM. Serum samples were extracte...
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Article
Open AccessComparison of smokers’ mortality with non-smokers following out-of-hospital cardiac arrests: a systematic review and meta-analysis
Although some studies have linked smoking to mortality after out-of-hospital cardiac arrests (OHCAs), data regarding smoking and mortality after OHCAs have not yet been discussed in a meta-analysis. Thus, this...
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Article
Rutin Attenuates Gentamycin-induced Hair Cell Injury in the Zebrafish Lateral Line via Suppressing STAT1
Aminoglycoside antibiotics, including gentamicin (GM), induce delayed ototoxic effects such as hearing loss after prolonged use, which results from the death of hair cells. However, the mechanisms underlying t...
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Article
A case of fatal poisoning caused by etomidate: evidence from pathological and toxicological analyses
Etomidate is a nonbarbiturate sedative derived from imidazole. Prolonged and excessive use of etomidate can lead to the suppression of adrenocortical function, myoclonus, and even death. This report describes ...
