82 Result(s)

Article

The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma

Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) re...

Song Tong, Ni Jiang, Jun-Hao Wan, Chong-Rui Chen, Si-Hua Wang, Chuang-Yan Wu… in BMC Cancer (2023)

Article

Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their associat...

Dingwei Ye, Jayesh Desai, **gwen Shi, Si-Yang Maggie Liu, Wei Shen… in Biomarker Research (2023)

Article

Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia

Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG) plays a role in streptozotocin (STZ)-induced DNP but the under...

**ao-fen He, Yu-rong Kang, Xue-yu Fei, Lu-hang Chen, **ang Li… in Purinergic Signalling (2023)

Article

Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

**ao Liu, Fei Hao, Peng Hao, **gxue Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen… in Signal Transduction and Targeted Therapy (2023)

Article

Retraction Note: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance

Yu-Nan Ma, Yong-Gang Hong, Guan-Yu Yu, Si-yuan Jiang… in Cancer Cell International (2023)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Risk stratification and prognostic value of multi-modal MRI-based radiomics for extranodal nasal-type NK/T-cell lymphoma

Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

Yu-Ting Zhao, Si-Ye Chen, **n Liu, Yong Yang, Bo Chen, Yong-Wen Song… in BMC Cancer (2023)

Article

Editorial expression of concern: Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

Fei Wang, **-Lian Yang, Ke-ke Yu, Mei Xu, You-zhi Xu, Li Chen… in Molecular Cancer (2022)

Article

CT Scans and Cancer Risks: A Systematic Review and Dose-response Meta-analysis

There is still uncertainty on whether ionizing radiation from CT scans can increase the risks of cancer. This study aimed to identify the association of cumulative ionizing radiation from CT scans with pertain...

Chun-Feng Cao, Kun-Long Ma, Hua Shan, Tang-Fen Liu, Si-Qiao Zhao, Yi Wan… in BMC Cancer (2022)

Article

Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. ...

Tai Xu, Si-Ming Zhang, He-Ming Wu, **ao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang… in BMC Cancer (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Correction: A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

Qian-wen Luo, Shan Gao, **ao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han… in BMC Cancer (2022)

Article

A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

Central lymph node status in papillary thyroid microcarcinoma (PTMC) plays an important role in treatment decision-making clinically, however, it is not easy to predict central lymph node metastasis (CLNM). Th...

Qian-wen Luo, Shan Gao, **ao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han… in BMC Cancer (2022)

Article

KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

Kinase suppressor of Ras 2 (KSR2) is a regulator of MAPK signaling that is overactivated in most hepatocellular carcinoma (HCC). We sought to determine the role of KSR2 in HCC pathogenesis.

Chao Gao, Si-wei Wang, Jia-cheng Lu, **ao-qiang Chai, Yuan-cheng Li… in Biomarker Research (2022)

Article

Retraction Note: MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via downregulation of GADD45α

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-015-0465-3.

Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang… in Molecular Cancer (2022)

Article

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization

Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy induction is one of the hallmark effects of anti-GB...

Zhuang Li, Wen-Juan Fu, **ao-Qing Chen… in Journal of Experimental & Clinical Cancer … (2022)

Article

Current applications and future perspective of CRISPR/Cas9 gene editing in cancer

Clustered regularly interspaced short palindromic repeats (CRISPR) system provides adaptive immunity against plasmids and phages in prokaryotes. This system inspires the development of a powerful genome engine...

Si-Wei Wang, Chao Gao, Yi-Min Zheng, Li Yi, Jia-Cheng Lu… in Molecular Cancer (2022)

Article

Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

Immune checkpoint blockade resistance narrows the efficacy of cancer immunotherapies, but the underlying mechanism remains elusive. Delineating the inherent mechanisms of anti-PD1 resistance is important to im...

Jia-Cheng Lu, Peng-Fei Zhang, **ao-Yong Huang… in Journal of Hematology & Oncology (2021)