1,395 Result(s)

Article

BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo

Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will in...

Qihong Yang, Kenneth Kin Wah To, Guilin Hu, Kai Fu… in Cell Communication and Signaling (2024)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...

Pengfei Zhang, Ju Yang, **ong Liu, Congshu Huang, Yuandong Tao… in Cell Death & Disease (2024)

Article

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...

Sanshan **, Shimeng Guo, Youwei Xu, **n Li, Canrong Wu, **nheng He… in Cell Discovery (2024)

Article

Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF

Dysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer, promotes tumorigenesis, inactivating tumor-suppressor genes and activating ...

Botao Pan, Can Liu, Jiyan Su, Chenglai **a in Cell Communication and Signaling (2024)

Article

TGF-β signaling regulates differentiation of MSCs in bone metabolism: disputes among viewpoints

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into cells of different lineages to form mesenchymal tissues, which are promising in regard to treatment for bone diseases. Their oste...

Erfan Wei, Menglong Hu, Likun Wu, **ngtong Pan, Qiyue Zhu… in Stem Cell Research & Therapy (2024)

Article

Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7

Kaixuan Zeng, **aoxiang Chen, Mu Xu, **angxiang Liu, **uxiu Hu… in Cell Death & Disease (2024)

Article

A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression

Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA in cancer. In this study...

Shanshan Qin, Qiwei Guo, Yue Liu, **angang Zhang, Pan Huang… in Cell Death & Disease (2024)

Article

IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy

Glutamine addiction represents a metabolic vulnerability of cancer cells; however, effective therapeutic targeting of the pathways involved remains to be realized. Here, we disclose the critical role of interf...

Yabin Huang, Fanzheng Meng, Taofei Zeng, Rick Francis Thorne, Lifang He… in Cell Discovery (2024)

Article

Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction

Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye diseases. Here, we reported that the kri1l gene was responsible for ...

Rong Zhang, Jiajun Sun, Yabin **e, Wei Zhu, Meitong Tao, Yu Chen… in Cell Death Discovery (2024)

Article

Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging

Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) and the age-related disorders. However, how does CRMs alter ...

Guofang **a, Simeng Zhu, Yujia Liu, **gwei Pan… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Vacuolar protein sorting 35 (VPS35) acts as a tumor promoter via facilitating cell cycle progression in pancreatic ductal adenocarcinoma

Yanzhi Gai, Liheng Qian, Shuheng Jiang, Jun Li… in Functional & Integrative Genomics (2024)

Article

Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

In the tumor immune microenvironment (TIME), triggering receptor expressed on myeloid cells 2 (trem2) is widely considered to be a crucial molecule on tumor-associated macrophages(TAMs). Multiple studies have ...

Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai… in Cell Communication and Signaling (2024)

Article

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regu...

Zi-Hui Mao, Zhong-**uzi Gao, Shao-Kang Pan, Dong-Wei Liu… in Cell Death Discovery (2024)