44 Result(s)
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Article
Shuanglin **ang
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Open AccessComprehensive analysis of coding-lncRNA gene co-expression network uncovers conserved functional lncRNAs in zebrafish
Zebrafish is a full-developed model system for studying development processes and human disease. Recent studies of deep sequencing had discovered a large number of long non-coding RNAs (lncRNAs) in zebrafish. ...
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Open AccessBased on virtual beamforming cooperative jamming with Stackelberg game for physical layer security in the heterogeneous wireless network
The physical layer security technology is a technical scheme developed in recent years to solve the problem of information security transmission in wireless communication networks. As one of the physical layer...
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Open AccessA Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies
Recently, there is increasing interest to detect associations between rare variants and complex traits. Rare variant association studies usually need large sample sizes due to the rarity of the variants, and l...
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Open AccessAn Adaptive Fisher’s Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies
Currently, the analyses of most genome-wide association studies (GWAS) have been performed on a single phenotype. There is increasing evidence showing that pleiotropy is a widespread phenomenon in complex dise...
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Open AccessTNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells
Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein th...
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Gravitational wave astronomy: the current status
In the centenary year of Einstein’s General Theory of Relativity, this paper reviews the current status of gravitational wave astronomy across a spectrum which stretches from attohertz to kilohertz frequencies...
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Open AccessTesting optimally weighted combination of variants for hypertension
Testing rare variants directly is possible with next-generation sequencing technology. In this article, we propose a sliding-window-based optimal-weighted approach to test for the effects of both rare and comm...
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Open AccessDetecting association of rare and common variants by testing an optimally weighted combination of variants with longitudinal data
Increasing evidence shows that complex diseases are caused by both common and rare variants. Recently, several statistical methods for detecting associations of rare variants have been developed, including the...
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TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1
The broad-complex, tramtrack, and bric-a-brac/poxvirus and zinc finger domain-containing protein tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) was first identified as a gene whose expression can be ...
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Open AccessDetection of rare variant effects in association studies: extreme values, iterative regression, and a hybrid approach
We develop statistical methods for detecting rare variants that are associated with quantitative traits. We propose two strategies and their combination for this purpose: the iterative regression strategy and ...
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CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA
TNFAIP1 is a protein which can be induced by tumor necrosis factorα (TNFα) and interleukin-6 (IL-6), it may play roles in DNA synthesis, DNA repair, cell apoptosis and human diseases. However, very little has ...
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Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells
The use of aspirin is associated with a lower risk of many cancer types. However, there are few reports about cervical cancer. The proto-oncogene ErbB2 is overexpressed in cervical cancer, and considered as a ...
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Functional characterization of the promoter region of human TNFAIP1 gene
Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an immediate-early response gene of endothelium induced by TNF alpha. However, little is really known concerning the TNFAIP1 expression regulation. T...
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Open AccessDetecting susceptibility genes for rheumatoid arthritis based on a novel sliding-window approach
With the recent rapid improvements in high-throughout genoty** techniques, researchers are facing a very challenging task of large-scale genetic association analysis, especially at the whole-genome level, wi...
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Open AccessA combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data
Rheumatoid arthritis is inherited in a complex manner. So far several single susceptibility genes, such as PTPN22, STAT4, and TRAF1-C5, have been identified. However, it is presumed that some genes may interact t...
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Open AccessGenome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis
Amyotrophic lateral sclerosis (ALS) is a fatal, degenerative neuromuscular disease characterized by a progressive loss of voluntary motor activity. About 95% of ALS patients are in "sporadic form"-meaning thei...
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Open AccessGenome-wide association tests by using block information in family data
By applying an association test to analyze the data sets from Genetic Analysis Workshop 15 Problem 3, we compare power using different haplotype-block information. The results from using both of the two differ...
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Open AccessGenome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals
Multiple testing is a problem in genome-wide or region-wide association studies. In this report, we consider a study design given by the Genetic Analysis Workshop 15 (GAW15) Problem 3 – nuclear families (paren...
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Open AccessA method dealing with a large number of correlated traits in a linkage genome scan
We propose a method to perform linkage genome scans for many correlated traits in the Genetic Analysis Workshop 15 (GAW15) data. The proposed method has two steps: first, we use a clustering method to find the...
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Open AccessA multi-marker test based on family data in genome-wide association study
Complex diseases are believed to be the results of many genes and environmental factors. Hence, multi-marker methods that can use the information of markers from different genes are appropriate for map** com...
