1,019 Result(s)
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Article
Qiu-** Zhang
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Genetic relationship analysis and fingerprint construction of some species in the genus Vanda (Orchidaceae) by interprimer binding site (iPBS) markers
Plants of the genus Vanda exhibit a diverse array of leaf shapes, with the number of flowers varying from a few to many, and a rich palette of colours. These characteristics render them highly valuable for orname...
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Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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4-Octyl Itaconate Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis Via Regulating Microglia
Abnormal activation of microglia, the resident macrophages in the central nervous system, plays an important role in the pathogenesis of multiple sclerosis (MS). The immune responsive gene 1(IRG1)/itaconate ax...
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A Self-Healing Elastomer with Extremely High Toughness Achieved by Acylsemicarbazide Hydrogen Bonding and Cu2+-Neocuproine Coordination Interactions
Elastomers with high mechanical toughness can guarantee their durability during service life. Self-healing ability, as well as recyclability, can also extend the life of materials and save the consuming cost o...
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Open AccessAnti-inflammatory properties and characterization of water extracts obtained from Callicarpa kwangtungensis Chun using in vitro and in vivo rat models
Callicarpa kwangtungensis Chun (CK) is a common remedy exhibits anti-inflammatory properties and has been used in Chinese herbal formulations, such as KangGongYan tablets. It is the main component of KangGongYan ...
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Open AccessDeficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
Hepatic encephalopathy (HE) is closely associated with inflammatory responses. However, as a crucial regulator of the immune and inflammatory responses, the role of leucine-rich repeat kinase 2 (LRRK2) in the ...
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Open AccessPD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression
Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molec...
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Mechanism development of strength contributed by CPB with rice husk ash
Rice husk ash (RHA) is currently utilized as a supplementary cementitious material in cement products due to its pozzolanic properties. This study aims to investigate the pozzolanic effect (PE) and filler effe...
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Two New Anti-SARS-CoV-2 Naphthoquinones from Cigar-Tobacco-Derived Endophytic Fusarium oxysporum
In this study, two new naphthoquinones, 6-isopropyl-7-methoxy-2-(2-oxopropyl)naphthalene-1,4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl)naphthalene-1,4-dione (2), together with five known new naphthoquino...
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Two New Aromatic Sesquiterpenes from the Leaves of Nicotiana tabacum and Their Aroma Character
Two new aromatic sesquiterpenes, 7-isopropyl-2,2,5-trimethyl-2H-chromene (1) and 7-isopropyl-5- (methoxymethyl)-2,2-dimethyl-2H-chromene (2), were isolated from the leaves of Nicotiana tabacum (a mutant tobacco f...
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Two New Antibacterial Isoindolin-1-Ones from Sun-Cured Tobacco and Their Potential Application in Antiseptic Cigarette Tip** Paper
Two new isoindolin-1-ones (1 and 2), were isolated from the stems of Nicotiana tabacum (a cultivar of sun-cured tobacco with high resistance to black shank diseases, which originated from Huize local sun-cured to...
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Two New Stilbenes from the Whole Plant of Arundina graminifolia and Their Anti-SARS-CoV-2 Activity
Two new stilbenes, 5-methoxy-6-(4-methoxystyryl)-3-methylbenzofuran (1) and 5-methoxy-6-(4- hydroxystyryl)-3-methylbenzofuran (2), together with six known ones, bauhiniastatin D (3), gramideoxybenzoin B (4), gram...
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Prenylated Flavonoids from Desmodium caudatum and as Potential Activators for SARS-CoV-2
Two new isoprenylated flavone, 8,4′-dimethoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (1), 8-hydroxy-4′-methoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (2), together with seven known isoprenylated flavonoids (3–9) were i...
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Bioactivity Isochromenes from Cigar Tobacco-Derived Endophytic Fungus Aspergillus fumigatus
Two new isochromenes, 1-(8-methoxy-3-methyl-1H-isochromen-6-yl)propan-1-one (1) and 3-hydroxy-1-(8- methoxy-3-methyl-1H-isochromen-7-yl)propan-1-one (2), along with five known ones, (3–7) were isolated from the f...
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Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis
Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome.
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Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation
Lethal graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem-cell transplantation (Allo-HSCT). Pyruvate kinase M2 (PKM2) is essential for CD4+ T-cell differentiation. Usin...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...
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Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
Ulcerative colitis (UC) is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis, necroptosis of epithelial cells, and mucosal ulcerations. Liver dysfunction and abnormal l...
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Open AccessMelatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol...
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P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult
P2X7 receptor (P2X7R) plays an important role in modulating inflammation and fibrosis, but information is limited whether Zusanli (ST36) can inhibit inflammation and fibrosis by regulating P2X7R. Isoprenaline ...
