13,109 Result(s)

Article

HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage

Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...

JianYe Yuan, Lin Guo, JiaTing Ma, HeJian Zhang… in Cell Biology and Toxicology (2024)

Article

Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells

Numerous studies have shown that somite development is a necessary stage of myogenesis chondrogenesis and osteogenesis. Our previous study has established a stable presomitic mesoderm progenitor cell line (UiP...

Huiru Gao, **ngnan Huang, Zepo Cai, Baomei Cai, Kaipeng Wang… in Cell & Bioscience (2024)

Article

Retraction Note: LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

Ru-nan Zhang, Dong-mei Wu, Li-** Wu, Guo-wei Gao in Cancer Cell International (2024)

Article

m¹A demethylase Alkbh3 regulates neurogenesis through m¹A demethylation of Mmp15 mRNA

N¹-Methyladenosine (m¹A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m¹A modification in adult hi...

Huan Wang, Linjie **e, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan… in Cell & Bioscience (2024)

Article

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, **ang** Zheng, Liwen Ren… in Signal Transduction and Targeted Therapy (2024)

Article

GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress

Acetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116) is an important homeostatic maintenance molecule in the body, but litt...

Qian **ang, Na Li, Yan Zhang, Ting Wang, Ying Wang… in Cellular and Molecular Life Sciences (2024)

Article

IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages

In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...

Jiayu Zhang, Yu Dong, Shan Yu, Keshu Hu, Lingyun Zhang, Min **ong… in Cell Death & Disease (2024)

Article

The influence of sex-specific factors on biological transformations and health outcomes in aging processes

The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of...

Yongyin Huang, Hongyu Li, Runyu Liang, Jia Chen, Qiang Tang in Biogerontology (2024)

Article

Neutrophil-derived migrasomes are an essential part of the coagulation system

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...

Dong Jiang, Lin Jiao, Qing Li, Renxiang **e, Haohao Jia, ShiHui Wang… in Nature Cell Biology (2024)

Article

TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway

The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF receptor-associated factor 6 (TRAF6) is associated with multiple inflammatory disea...

Yu Zhao, Tiegang Li, Lichun Zhang, Jun Yang, Feng Zhao… in Cell Biology and Toxicology (2024)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Identification of Potential Biomarkers for Patients with DWI-Negative Ischemic Stroke

Ischemic stroke is the leading cause of long-term disability in adults, accounting for 80% of stroke cases. Diffusion weighted imaging (DWI) examination is the main test for acute ischemic stroke, but in recen...

Lei Li, Ying Wang in Journal of Molecular Neuroscience (2024)

Article

Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma

The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumo...

Deming Li, Ting Zhang, Ye Guo, Cong Bi, Ming Liu, Gang Wang in Cell Death & Disease (2024)

Article

Structural basis of tethered agonism and G protein coupling of protease-activated receptors

Protease-activated receptors (PARs) are a unique group within the G protein-coupled receptor superfamily, orchestrating cellular responses to extracellular proteases via enzymatic cleavage, which triggers intr...

Jia Guo, Yun-Li Zhou, Yixin Yang, Shimeng Guo, Erli You, **n **e, Yi Jiang… in Cell Research (2024)

Article

Correction: Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats

Danyang Zheng, Henan Zhou, Hongchen Wang, Yu Zhu, Yue Wu… in Stem Cell Research & Therapy (2024)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Correction to: Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes

Yingjiao Liu, Shifeng Chu, Yaomei Hu, Songwei Yang… in Cellular and Molecular Neurobiology (2024)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8⁺ T lymphocytes

Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have illustrated the roles of N⁶-methyladenosine (m⁶A) on NSCLC immune evasion...

Yisheng Luo, Chao Zeng, Zezhong Ouyang, Wenbin Zhu, Jiazhi Wang… in Cell Death Discovery (2024)