480 Result(s)

Article

Molecular basis and homeostatic regulation of Zinc taste

Rui Luo, Yuxiang Zhang, Yinjun Jia, Yan Zhang, Zongyang Li, Jieqing Zhao… in Protein & Cell (2022)

Article

Correction to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

The original article can be found online at https://doi.org/10.1007/s13238-021-00837-8.

Chuan Chen, Wenqiang Liu, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu… in Protein & Cell (2022)

Article

Ferroptosis as an important driver of lupus

Chao Mao, Guang Lei, Li Zhuang, Boyi Gan in Protein & Cell (2022)

Article

Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome

Yu-Sheng Chen, Shuaiyao Lu, Bing Zhang, Tingfu Du, Wen-Jie Li, Meng Lei… in Protein & Cell (2022)

Article

Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis

Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive. Here we demonstrated that the SGLT2 inhibitor,...

Kai Jiang, Yue Xu, Dandan Wang, Feng Chen, Zizhuo Tu, Jie Qian, Sheng Xu… in Protein & Cell (2022)

Article

Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing

Recent advances in genome editing, especially CRISPR-Cas nucleases, have revolutionized both laboratory research and clinical therapeutics. CRISPR-Cas nucleases, together with the DNA damage repair pathway in ...

**ya Zhang, Tao Li, Jian** Ou, Junjiu Huang, Pu** Liang in Protein & Cell (2022)

Article

Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells

The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized...

Lei Chang, Mengfan Li, Shipeng Shao, Chen Li, Shanshan Ai, Boxin Xue… in Protein & Cell (2022)

Article

Identification of a novel cDC2-committed progenitor within mouse common dendritic cell progenitor population

Yujie Tian, Xueheng Guo, Tao Wu, Kuangyu Fei, Li Wu in Protein & Cell (2022)

Article

Drug target inference by mining transcriptional data using a novel graph convolutional network framework

A fundamental challenge that arises in biomedicine is the need to characterize compounds in a relevant cellular context in order to reveal potential on-target or off-target effects. Recently, the fast accumula...

Feisheng Zhong, **aolong Wu, Ruirui Yang, Xutong Li, Dingyan Wang… in Protein & Cell (2022)

Article

Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome

Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, and visual stimuli. Like FXS in humans, loss of Fmr1

Chaojuan Yang, Yonglu Tian, Feng Su, Yangzhen Wang, Mengna Liu… in Protein & Cell (2022)

Article

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

**ghui Lei, **aoyu Jiang, Wei Li, Jie Ren, Datao Wang, Zhejun Ji… in Protein & Cell (2022)

Article

Cancer biology deciphered by single-cell transcriptomic sequencing

Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune, endothelial, and stromal cells. Cancer biology had been studied using bulk gen...

Yanmeng Li, Jianshi **, Fan Bai in Protein & Cell (2022)

Article

A pair of transporters controls mitochondrial Zn²⁺ levels to maintain mitochondrial homeostasis

Zn²⁺ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn²⁺ level is achieved ...

Tengfei Ma, Liyuan Zhao, Jie Zhang, Ruofeng Tang, **n Wang, Nan Liu… in Protein & Cell (2022)

Article

Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes

Beili Chen, Jianying Guo, Ting Wang, Qianhui Lee, Jia Ming, Fangfang Ding… in Protein & Cell (2022)

Article

Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells

The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectiv...

Hongling Zhang, Yuanyuan Li, Yongjian Ma, Chong** Lai, Qian Yu… in Protein & Cell (2022)

Article

Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer

Bing Liu, Daniela Duenas, Li Zheng, Karen Reckamp, Binghui Shen in Protein & Cell (2022)

Article

cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence

As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, w...

**aocui Li, **aojuan Li, Chen **e, Sihui Cai, Mengqiu Li, He** **… in Protein & Cell (2022)

Article

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting...

Weili Yang, **angyu Guo, Zhuchi Tu, **usheng Chen, Rui Han, Yanting Liu… in Protein & Cell (2022)

Article

Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy

Bin Li, Yongkun Zhan, Qianqian Liang, Chen Xu, **nyan Zhou, Huanhuan Cai… in Protein & Cell (2022)

Article

A tribute to Professor Yong Zhao

Zheng Tan, Jun Tang, Feng Wang, **aocui Li, Yanlian Chen, Zhou Songyang in Protein & Cell (2022)